Antibiotic artificial bone implantation for the treatment of infection after internal fixation of tibial plateau fractures

Article Orthopedics

Treatment of chronic osteomyelitis with antibiotic-impregnated polymethyl methacrylate (PMMA) - the Cierny approach: is the second stage necessary?

Noam Bor et al.

Summary: The study suggests that in a proportion of patients with planned retention of ACS, they appear to function well without requiring further surgical intervention, especially in elderly or vulnerable patients.

BMC MUSCULOSKELETAL DISORDERS (2022)

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Article Orthopedics

Antibiotic artificial bone implantation and external fixation for the treatment of infection after intramedullary nail fixation: a retrospective study of 33 cases

Haotian Hua et al.

Summary: Antibiotic artificial bone implantation and external fixation is an effective method for the treatment of infection after intramedullary nail fixation, which can control the infection and promote fracture healing.

BMC MUSCULOSKELETAL DISORDERS (2022)

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Review Orthopedics

Use of contemporary biomaterials in chronic osteomyelitis treatment: Clinical lessons learned and literature review

Jan A. P. Geurts et al.

Summary: Chronic osteomyelitis poses challenges in treatment due to bone infection and bacterial biofilm eradication. Novel biomaterials with unique properties are increasingly used to combat infection in this context, with ongoing debate about focusing on bone regeneration or antimicrobial properties.

JOURNAL OF ORTHOPAEDIC RESEARCH (2021)

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Article Cell & Tissue Engineering

Antibacterial calcium phosphate cement with human periodontal ligament stem cell-microbeads to enhance bone regeneration and combat infection

Gengtao Qiu et al.

Summary: The novel CPCC + DOX scaffold demonstrated excellent mechanical properties and strong antibacterial activity, while also supporting proliferation and osteogenic differentiation of hPDLSCs. This scaffold has the potential to enhance bone regeneration and combat bone infections in dental, craniofacial, and orthopedic applications.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Article Engineering, Biomedical

A novel biocomposite scaffold with antibacterial potential and the ability to promote bone repair

Kai Li et al.

Summary: The self-assembling peptide RADA shows great potential in promoting bone regeneration by enhancing osteoblast proliferation, differentiation, and mineralization. The RADA-CPC scaffold, combining RADA and calcium phosphate cement, has potential applications in orthopedics for bone repair and infection prevention.

JOURNAL OF BIOMATERIALS APPLICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Uncoated vs. Antibiotic-Coated Tibia Nail in Open Diaphyseal Tibial Fracture (42 according to AO Classification): A Single Center Experience

Tommaso Greco et al.

Summary: Antibiotic-coated nails are crucial in the treatment of open tibia fractures, improving fracture healing rate and reducing infection rate. This study found no deep wound infections when using antibiotic-coated nails, and good fracture healing outcomes.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Orthopedics

Gastrocnemius muscle flap with vancomycin/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery

Weiwei Ruan et al.

Summary: The study showed that in the initial treatment of traumatic focal osteomyelitis, using gastrocnemius muscle flaps combined with vancomycin/gentamicin-calcium sulfate and autologous iliac bone graft could improve the clinical outcomes of patients.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Article Cell & Tissue Engineering

Management of surgical site infection post-open reduction and internal fixation for tibial plateau fractures

J. Shen et al.

Summary: The study investigates the effect of induced membrane technique combined with internal fixation for managing surgical site infection (SSI) in tibial plateau fracture (TPF) patients who underwent open reduction and internal fixation (ORIF). The results show that this treatment approach leads to satisfactory outcomes in terms of infection control and functional recovery in TPF patients with SSI post-ORIF.

BONE & JOINT RESEARCH (2021)

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Article Health Care Sciences & Services

Clinical observations of vancomycin-loaded calcium phosphate cement in the 1-stage treatment of chronic osteomyelitis: a randomized trial

Zhi-Gang Lang et al.

Summary: This study explored the clinical effects of vancomycin-loaded calcium phosphate cement (CPC) in treating chronic osteomyelitis in 98 patients. Results showed that one-stage treatment with vancomycin-loaded CPC effectively filled bone lesions, induced bone defect osteogenesis, and reduced recurrence rates of chronic osteomyelitis, with high cure rates observed. The study was registered on the Chinese Clinical Trial Registry website (ChiCTR2100044724).

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Orthopedics