Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 94, Issue 7, Pages 609-622Publisher
WILEY
DOI: 10.1002/jnr.23732
Keywords
traumatic brain injury; cerebrovascular dysfunction; neurovascular dysfunction
Categories
Funding
- National Institute of Neurological Disorders and Stroke [1 P01 NS082184-01A1]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD061946]
- Fondation des gueules cassees
- EraNet Neuron CNS-Aflame
- TRAIL-ANR investissement d'avenir, France
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Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long-term alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. This Review focuses on the different types of cerebrovascular dysfunction that occur after TBI, including cerebral blood flow alterations, autoregulation impairments, subarachnoid hemorrhage, vasospasms, blood-brain barrier disruption, and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade. (C) 2016 Wiley Periodicals, Inc.
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