Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 95, Issue 8, Pages 1690-1699Publisher
WILEY
DOI: 10.1002/jnr.24000
Keywords
Long non-coding RNA; superior cervical ganglia; stellate ganglia; diabetic cardiac autonomic neuropathy; RRID: RGD_734476; RRID: SCR_004899
Categories
Funding
- National Natural Science Foundation of China [81200853, 81570735, 31560276, 81560219, 81560529, 81460200, 81360436, 81171184, 31060139, 81360140]
- young scientist training object of Jiangxi Province [20153BCB23030]
- Technology Pedestal and Society Development Project of Jiangxi Province [20151122040105]
- Natural Science Foundation of Jiangxi Province [20142BAB205028]
- Educational Department of Jiangxi Province [GJJ13155, GJJ14319]
Ask authors/readers for more resources
Cardiac autonomic neuropathy in Type 2 diabetes (T2D) is often a devastating complication. Long non-coding RNAs (lncRNAs) have important effects on both normal development and disease pathogenesis. In this study, we explored the expression profiles of some lncRNAs involved in inflammation which may be co-expressed with messenger RNA (mRNA) in superior cervical and stellate ganglia after type 2 diabetic injuries. Total RNA isolated from 10 pairs of superior cervical and stellate ganglia in diabetic and normal male rats was hybridized to lncRNA arrays for detections. Pathway analysis indicated that the most significant gene ontology (GO) processes that were upregulated in diabetes were associated with immune response, cell migration, defense response, taxis, and chemotaxis. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway revealed that most of the target genes of the lncRNAs were located in cytokine-cytokine receptor interactions, the chemokine signaling pathway and cell adhesion molecules, which were involved in T2D. Gene co-expression network construction showed that the co-expression network in the experimental rats consisted of 268 regulation edges among 105 lncRNAs and 11 mRNAs. Our studies demonstrated the co-expression profile of lncRNAs and mRNAs in diabetic cardiac autonomic ganglia, suggesting possible roles for multiple lncRNAs as potential targets for the development of therapeutic strategies or biomarkers for diabetic cardiac autonomic neuropathy. (c) 2016 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available