Oral mycobiota and pancreatic ductal adenocarcinoma

Article Environmental Sciences

Association between residential greenness and gut microbiota in Chinese adults

Kunpeng Wu et al.

Summary: This study found that higher levels of residential greenness are associated with healthier gut microbiota, characterized by increased microbial diversity and specific taxonomic composition.

ENVIRONMENT INTERNATIONAL (2022)

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Article Immunology

Alterations of Gut Mycobiota Profiles in Adenoma and Colorectal Cancer

Renyuan Gao et al.

Summary: This study revealed the alterations of gut mycobiota in colorectal cancer and adenoma patients and established a reliable diagnostic model for colorectal cancer, which is of great importance for future treatment strategies.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Gastroenterology & Hepatology

Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses

Yufeng Lin et al.

Summary: This study reveals the signatures of the enteric mycobiota and pathogenic fungi in stages of colorectal tumorigenesis. Fecal fungi, in addition to bacteria, can be used for noninvasive diagnosis of patients with colorectal cancer.

GASTROENTEROLOGY (2022)

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Article Biochemistry & Molecular Biology

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

Anders B. Dohlman et al.

Summary: Fungal microorganisms, particularly Candida, play a significant role in the pathogenesis of gastrointestinal cancers, including lung, stomach, and colon cancers. Their presence is associated with immune response, metastatic disease, and decreased survival, suggesting that tumor-associated fungal DNA may serve as diagnostic or prognostic biomarkers.

CELL (2022)

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Article Environmental Sciences

High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: Results from the China multi-ethnic cohort (CMEC) study

Haojiang Zuo et al.

Summary: High-altitude exposure may lead to decreased bone mineral density in adults, increasing the risk of osteoporosis. Modulating gut microbiota could be a potential strategy for alleviating the decrease in bone mineral density.

ENVIRONMENTAL RESEARCH (2022)

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Letter Surgery

Symptom evaluation in pancreatic cancer detection

Jue Yuan et al.

ASIAN JOURNAL OF SURGERY (2021)

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Article Biochemistry & Molecular Biology

Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22

Yanan Zhu et al.

Summary: Mice lacking Dectin-3 showed increased tumorigenesis and Candida albicans burden, leading to enhanced IL-22 production in innate lymphoid cells, highlighting the significance of commensal fungi in regulating host immunity and promoting tumorigenesis.

EMBO JOURNAL (2021)

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Article Gastroenterology & Hepatology

Fecal Mycobiota Combined With Host Immune Factors Distinguish Clostridioides difficile Infection From Asymptomatic Carriage

Yangchun Cao et al.

Summary: Our study identified significant differences in alpha and beta diversity between patients with CDI and asymptomatic carriers, with enrichment of Cladosporium and Aspergillus genera in carriers. The ratio of Ascomycota to Basidiomycota was notably higher in CDI patients. Using a combination of fungal operational taxonomic units and host immune markers in a random forest classifier achieved high performance in distinguishing CDI patients from carriers.

GASTROENTEROLOGY (2021)

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Article Multidisciplinary Sciences

Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice

Umang Jain et al.

Summary: The study revealed that Debaryomyces hansenii fungus inhabits incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD patients, impairing colonic healing. Mechanistically, D. hansenii affects mucosal healing through the myeloid cell-specific type 1 interferon-CCL5 axis.

SCIENCE (2021)

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Article Immunology

Analysis of Salivary Mycobiome in a Cohort of Oral Squamous Cell Carcinoma Patients From Sudan Identifies Higher Salivary Carriage of Malassezia as an Independent and Favorable Predictor of Overall Survival

Nazar Mohamed et al.

Summary: The study revealed significant differences in the fungal composition patterns in saliva from oral squamous cell carcinoma (OSCC) patients compared to individuals without OSCC. The fungal genus Malassezia was identified as a potential prognostic biomarker and therapeutic target for OSCC.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Oncology

LncRNA CRNDE promotes the progression and angiogenesis of pancreatic cancer via miR-451a/CDKN2D axis

Hong-Yan Zhu et al.

Summary: The study demonstrated that CRNDE is significantly up-regulated in pancreatic cancer tissues and cell lines, promoting cancer progression and angiogenesis through the miR-451a/CDKN2D axis. This suggests that CRNDE may serve as a potential therapeutic target for pancreatic cancer treatment.

TRANSLATIONAL ONCOLOGY (2021)

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Article Infectious Diseases

Species Diversity and Antifungal Susceptibilities of Oral Yeasts from Patients with Head and Neck Cancer

Jinyan Wu et al.

Summary: The study revealed a high prevalence of oral yeast colonization in head and neck cancer patients in Hainan, China, with certain yeast isolates showing resistance to antifungal drugs. Rapid identification and susceptibility testing should be implemented before antifungal treatment among these patients.

INFECTION AND DRUG RESISTANCE (2021)

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Review Oncology

Micro- and Mycobiota Dysbiosis in Pancreatic Ductal Adenocarcinoma Development

Ruben Bellotti et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality, with recent research focusing on the microbial community in the pancreas as a potential target for early diagnosis and treatment. Specific microbial signatures may serve as novel screening tools, and micro- and mycobiota may represent promising targets for PDAC therapy.

CANCERS (2021)

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Review Oncology

Mycobiome and Cancer: What Is the Evidence?

Natalia Vallianou et al.

Summary: Although the fungal community accounts for a smaller proportion of the human microbiome, recent research has shed light on its potential interactions with both the human bacteriome and the host. Various cancers, such as head and neck cancer, colorectal carcinoma, and pancreatic ductal adenocarcinoma, have shown associations with differences in the composition of the mycobiome. Fungi, particularly Malassezia and Schizophyllum, have been linked to the onset and progression of certain cancers, highlighting their potential as diagnostic tools or treatment targets in the future.

CANCERS (2021)

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Article Microbiology

Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis

Janina A. Krumbeck et al.

Summary: This study explored the role of bacteria and fungi in the feline oral microbiome, revealing a potential involvement of fungi in the etiology and pathogenesis of feline chronic gingivostomatitis. Additionally, specific bacteria in the oral microbiome of healthy cats may serve as potential biomarkers.

PATHOGENS (2021)

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Article Medicine, General & Internal

Comparative Study of Oral Bacteria and Fungi Microbiota in Tibetan and Chinese Han Living at Different Altitude

Ke Dong et al.

Summary: The study found significant differences in oral microbiota composition at the phylum and genus levels between Tibetan and Han populations, indicating the impact of altitude and ethnicity on oral microbiota. Tibetan individuals had higher abundances of certain bacteria and fungi compared to Han individuals, with different dominant genus compositions and distinct changes in microbial functions.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Medicine, Research & Experimental

Candida albicans disorder is associated with gastric carcinogenesis

Mengya Zhong et al.

Summary: This study identified an imbalance of gastric fungal microbiome associated with gastric cancer, characterized by altered fungal composition and ecology. Candida albicans was found to be a potential fungal biomarker for gastric cancer, with significant differences in fungal structure and diversity between gastric cancer and control groups. The study suggests that C. albicans could mediate gastric cancer by reducing the diversity and richness of stomach fungi.

THERANOSTICS (2021)

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Review Gastroenterology & Hepatology

Detecting Early Pancreatic Cancer: Current Problems and Future Prospects

Hiroyuki Matsubayashi et al.

GUT AND LIVER (2020)

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Article Multidisciplinary Sciences

CA19-9 for detecting recurrence of pancreatic cancer

Azadeh Azizian et al.

SCIENTIFIC REPORTS (2020)

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Carbohydrate antigen 19-9 elevation without evidence of malignant or pancreatobiliary diseases

Sunyoung Kim et al.

SCIENTIFIC REPORTS (2020)

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Review Oncology

Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis

Karolina Kazmierczak-Siedlecka et al.

CANCERS (2020)

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Review Medicine, General & Internal

Screening Strategy of Pancreatic Cancer in Patients with Diabetes Mellitus

Suguru Mizuno et al.

DIAGNOSTICS (2020)

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The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data

Axel Bengtsson et al.

SCIENTIFIC REPORTS (2020)

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Article Gastroenterology & Hepatology

Oral microbiome and pancreatic cancer

Ai-Lin Wei et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

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Article Immunology

Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China

Hao-Jiang Zuo et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Multidisciplinary Sciences

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

Berk Aykut et al.

NATURE (2019)

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Article Gastroenterology & Hepatology

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer

Olabisi Oluwabukola Coker et al.

GUT (2019)

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Review Biochemistry & Molecular Biology

Role of the microbiome in occurrence, development and treatment of pancreatic cancer

Yicheng Wang et al.

MOLECULAR CANCER (2019)

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Review Microbiology

Role of Oral Microbiota in Cancer Development

Tomasz M. Karpinski

MICROORGANISMS (2019)

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Article Multidisciplinary Sciences

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Joshua D. Cohen et al.

SCIENCE (2018)

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Investigation of Dietary Factors and Esophageal Cancer Knowledge: Comparison of Rural Residents in High- and Low-incidence Areas

Dong Tian et al.

SCIENTIFIC REPORTS (2018)

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Correction Multidisciplinary Sciences

Differentiated surface fungal communities at point of harvest on apple fruits from rural and peri-urban orchards (vol 8, 2018)

Youming Shen et al.

SCIENTIFIC REPORTS (2018)

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Article Immunology

The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

Tingting Wang et al.

IMMUNITY (2018)

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Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Yan He et al.

NATURE MEDICINE (2018)

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Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis

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GASTROENTEROLOGY RESEARCH AND PRACTICE (2018)

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Review Biotechnology & Applied Microbiology

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

Christopher Staley et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)

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Article Oncology

Cancer risk in patients with candidiasis: a nationwide population-based cohort study

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ONCOTARGET (2017)

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Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China

Zhigang Ren et al.

ONCOTARGET (2017)

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High Spicy Food Intake and Risk of Cancer: A Meta-analysis of Case-control Studies

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CHINESE MEDICAL JOURNAL (2017)

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A prospective cohort study on poor oral hygiene and pancreatic cancer risk

Jiaqi Huang et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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FUNGuild: An open annotation tool for parsing fungal community datasets by ecological guild

Nhu H. Nguyen et al.

FUNGAL ECOLOGY (2016)

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Article Microbiology

Malassezia arunalokei sp nov., a Novel Yeast Species Isolated from Seborrheic Dermatitis Patients and Healthy Individuals from India

Prasanna Honnavar et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2016)

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The Clinical Utility and Limitations of Serum Carbohydrate Antigen (CA19-9) as a Diagnostic Tool for Pancreatic Cancer and Cholangiocarcinoma

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Oral mycobiota and pancreatic ductal adenocarcinoma

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