Journal
BLOOD COAGULATION & FIBRINOLYSIS
Volume 34, Issue 3, Pages 228-231Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MBC.0000000000001196
Keywords
adrenal gland diseases; adrenal insufficiency; myeloproliferative disorders; anticoagulants; venous thrombosis
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Bilateral adrenal hemorrhage is a rare cause of adrenal insufficiency, and its association with myeloproliferative neoplasms is uncommon. This case report describes two octogenarian males with JAK2 V617F-positive essential thrombocythemia presenting with abdominal pain, malaise, and fatigue. Both patients were on long-term direct oral anticoagulant treatment for atrial fibrillation. Favorable outcomes were achieved with steroid replacement therapy, cytoreduction, aspirin, and switching to vitamin K antagonists.
Bilateral adrenal hemorrhage is a rare cause of adrenal insufficiency which has been rarely associated with myeloproliferative neoplasms. Here, we report two cases of bilateral adrenal hemorrhage revealed by abdominal pain, malaise, and fatigue in two octogenarian males previously diagnosed with JAK2 V617F-positive essential thrombocythemia. Both patients were on long-term direct oral anticoagulant treatment for atrial fibrillation. Evolution was favorable under steroid replacement therapy, associated with cytoreduction, aspirin, and switch of direct oral anticoagulants for vitamin K antagonists.
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