Chronic GVHD on the move

In this issue of Blood, Kong et al present an additional pathophysiologic link between autoimmune diseases and chronic graft-versus-host disease (GVHD).1 They demonstrate that peripheral T helper (Tph) cells and tissue -resident T helper (Trh) cells not only are clonally related but also are able to traffic between peripheral blood and target organs of chronic GVHD.

Automated summary

The study reveals a new pathophysiologic link between autoimmune diseases and chronic GVHD, showing the clonal relationship and trafficking abilities of peripheral T helper cells and tissue-resident T helper cells between blood and target organs.