Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 261, Issue -, Pages 29-46Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2015.11.029
Keywords
Magnetoencephalography (MEG); Local Field Potential (LFP); Deep Brain Stimulation (DBS); Parkinson's disease
Categories
Funding
- Medical Research Council [MR/K005464/1]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
- Wellcome Trust [091593/Z/10/Z]
- Medical Research Council [MR/K005464/1, MC_UU_12024/1, G0901503] Funding Source: researchfish
- Parkinson's UK [F-0903] Funding Source: researchfish
- MRC [MC_UU_12024/1, MR/K005464/1, G0901503] Funding Source: UKRI
Ask authors/readers for more resources
Background: Deep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order to gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required. New method: In this paper, we describe an experimental protocol and analysis pipeline for simultaneously performing DBS and intracranial local field potential (LFP) recordings at a target brain region during concurrent magnetoencephalography (MEG) measurement. Firstly we describe a phantom setup that allowed us to precisely characterise the MEG artefacts that occurred during DBS at clinical settings. Results: Using the phantom recordings we demonstrate that with MEG beamforming it is possible to recover oscillatory activity synchronised to a reference channel, despite the presence of high amplitude artefacts evoked by DBS. Finally, we highlight the applicability of these methods by illustrating in a single patient with Parkinson's disease (PD), that changes in cortical-subthalamic nucleus coupling can be induced by DBS. Comparison with existing approaches: To our knowledge this paper provides the first technical description of a recording and analysis pipeline for combining simultaneous cortical recordings using MEG, with intracranial LFP recordings of a target brain nucleus during DBS. (C) 2015 The Authors. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available