Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 45, Pages 11411-11417Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2360-16.2016
Keywords
actin; Arp2/3; autism; dendritic spine; NMDA receptor; schizophrenia
Categories
Funding
- Nancy Lurie Marks Family Foundation
- National Institutes of Health [MH103374, NS059957, MH043784, MH103204, DA037618, MH108842]
- Institute for Basic Science [R002-D1]
- Pfizer
- Ministry of Science, ICT & Future Planning, Republic of Korea [IBS-R002-D1-2016-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from humangenetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders.
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