4.7 Article

Design, synthesis, and metabolite identification of Tamoxifen esterase-activatable

Related references

Note: Only part of the references are listed.
Article Obstetrics & Gynecology

Gynecological management of the breast cancer survivor

Mary Kathryn et al.

Summary: Survival rates of breast cancer patients have been increasing since the 1990s, highlighting the importance of addressing quality of life and gynecologic concerns. Breast cancer diagnosis and treatment uniquely impact women's health issues such as contraception, pregnancy, menopause, and sexual functioning. Hormone-sensitive breast cancer accounts for two-thirds of cases, and adjuvant hormonal therapies have significantly reduced disease recurrence and contralateral breast cancer risk. However, these therapies can lead to menopausal and sexual side effects, requiring healthcare providers to be knowledgeable about safe and effective treatment options.

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY (2022)

Article Oncology

CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial

W. He et al.

Summary: This study found that poor CYP2D6 metabolizers are more likely to experience an impaired response to tamoxifen, while ultrarapid metabolizers are at risk for exaggerated response and may lead to treatment discontinuation.

ANNALS OF ONCOLOGY (2021)

Article Toxicology

Human Variability in Carboxylesterases and carboxylesterase-related Uncertainty Factors for Chemical Risk Assessment

E. Di Consiglio et al.

Summary: Carboxylesterases are important enzymes with large inter-individual variability, with most healthy adults covered by the kinetic default UF except for certain drugs like clopidogrel and dabigatran etexilate. Variability in drug metabolism and absorption may contribute to CES-related variability in vivo.

TOXICOLOGY LETTERS (2021)

Review Oncology

Clinical CYP2D6 Genotyping to Personalize Adjuvant Tamoxifen Treatment in ER-Positive Breast Cancer Patients: Current Status of a Controversy

Tessa A. M. Mulder et al.

Summary: Tamoxifen is a crucial adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer patients, with the conversion to the active metabolite endoxifen mainly depending on the CYP2D6 enzyme. Genetic variations in the CYP2D6 gene can impact endoxifen formation and therapy outcomes, though the correlation between CYP2D6 genotype and clinical outcome remains debated. Recent developments from 2018 to 2020 shed light on this ongoing debate.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Metabolic reprograming confers tamoxifen resistance in breast cancer

Alok Mishra et al.

Summary: Breast cancer is the most common cancer among females, and endocrine therapy for ER-positive breast cancer can result in acquired resistance. The metabolic state of cancer cells plays a crucial role in their susceptibility to chemotherapeutic drugs, and understanding metabolic pathway alterations in TAMR cancer may offer potential therapeutic strategies.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

Review Oncology

Tamoxifen and oxidative stress: an overlooked connection

Nermin S. Ahmed et al.

Summary: Tamoxifen is the gold standard drug for treating breast cancer, initially believed to work through estrogen receptor mechanism but later proven to act through multiple non-estrogen receptor mechanisms. Additionally, the connection between tamoxifen's apoptotic effects and oxidative stress is often overlooked.

DISCOVER ONCOLOGY (2021)

Review Oncology

Tamoxifen and Endometrial Cancer: A Janus-Headed Drug

Gunter Emons et al.

CANCERS (2020)

Letter Oncology

Tamoxifen Pharmacogenetics and Metabolism: The Same Is Not the Same

Hiltrud Brauch et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Review Pharmacology & Pharmacy

Human carboxylesterases: a comprehensive review

Dandan Wang et al.

ACTA PHARMACEUTICA SINICA B (2018)

Article Pharmacology & Pharmacy

Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms

Jian Shi et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2016)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues

Khaled R. A. Abdellatif et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Food Science & Technology

p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells

Zeina Dagher et al.

FOOD AND CHEMICAL TOXICOLOGY (2012)

Article Oncology

The NCI60 human tumour cell line anticancer drug screen

Robert H. Shoemaker

NATURE REVIEWS CANCER (2006)