Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 35, Pages 9084-9096Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0992-16.2016
Keywords
circadian; entrainment; photoreception; pigment dispersing factor
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Funding
- National Institutes of Health (National Institute of Neurological Disorders and Stroke) [R00NS062953, R01NS077933]
- German Research Foundation [DFG Fo207/10-3, SFB1047, INST 93/784-1]
- European Community [EUCLOCK 018741]
- Biotechnology and Biological Sciences Research Council [BB/J0127221/1]
- BMBF (German Ministry for Education and Research) Hanns-Seidel-Foundation Excellence Grant
- BBSRC [BB/J017221/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J017221/1] Funding Source: researchfish
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In animals, circadian clocks have evolved to orchestrate the timing of behavior and metabolism. Consistent timing requires the entrainment these clocks to the solar day, a process that is critical for an organism's health. Light cycles are the most important external cue for the entrainment of circadian clocks, and the circadian system uses multiple photoreceptors to link timekeeping to the light/dark cycle. How light information from these photorecptors is integrated into the circadian clock neuron network to support entrainment is not understood. Our results establish that input from the HB eyelets differentially impacts the physiology of neuronal subgroups. This input pathway, together with input from the compound eyes, precisely times the activity of flies under long summer days. Our results provide a mechanistic model of light transduction and integration into the circadian system, identifying new and unexpected network motifs within the circadian clock neuron network.
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