Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 156, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113921
Keywords
Exosome; CircRNA; Exosomal circRNA; Tumor angiogenesis
Funding
- National Natural Science Foundation of China
- [81972322]
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Recent studies have shown that circRNAs can regulate the tumor microenvironment through exosomes and serve as therapeutic targets. This review discusses the roles and potential applications of exosomal circRNAs in angiogenesis, as well as the related technological advancements.
Over the last few decades, our understanding of the molecular mechanisms underlying tumor angiogenesis has advanced at a significant pace and the clinical translation of these mechanisms has benefited millions of patients. However, limited efficacy and the rapid expansion of drug resistance remain unresolved issues. Recent studies in both preclinical and clinical settings have revealed that circRNAs, as a novel identified non-coding RNA can mediate intercellular communication and regulate the microenvironment within tumors after being selectively packaged, secreted, and transmitted via exosomes. This review aims to provide a comprehensive understanding of how exosomal circRNAs orchestrate inducers and inhibitors of angiogenesis, including their functions, mo-lecular mechanisms, and potential roles as diagnostic biomarkers and therapeutic targets. Finally, we discuss the technological advances in exosome functionalization and exosome-mimetic nanovesicles intending to improve the clinical translation of exosomal circRNAs.
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