4.7 Review

CD147 and MMPs as key factors in physiological and pathological processes

Related references

Note: Only part of the references are listed.
Article Biology

The Effects of EMMPRIN/CD147 on Late Function and Histopathological Lesions of the Renal Graft

Magdalena Nalewajska et al.

Summary: This study identified a negative correlation between EMMPRIN and long-term renal graft function, as well as associations with poorer kidney function, renal biopsy specimen lesions, and proteinuria.

BIOLOGY-BASEL (2022)

Article Cardiac & Cardiovascular Systems

CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults

Mohamed M. Ali et al.

Summary: Elevated levels of CD147 protein in obese and obese diabetic subjects are associated with vascular dysfunction and cardiometabolic risk factors.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2022)

Article Biochemistry & Molecular Biology

Homophilic Interaction of CD147 Promotes IL-6-Mediated Cholangiocarcinoma Invasion via the NF-κB-Dependent Pathway

Paweena Dana et al.

Summary: This study focused on the role of CD147 in promoting proinflammatory cytokine production in cholangiocarcinoma (CCA), revealing that CD147-regulated cytokines, such as IL-6, IL-8, and GM-CSF, play a critical role in CCA invasion. The findings suggest that modulation of CD147-related inflammation could be a promising therapeutic strategy for advanced CCA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives

Tapan Behl et al.

Summary: Neurodegeneration is a pathological condition where the nervous system or neuron loses structure and function, with no known treatment yet, and matrix metalloproteinases (MMPs) play a crucial role in the progression of neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia

Hao Chen et al.

Summary: CD147 plays a crucial role in promoting sperm motility and acrosome reaction, and could serve as a marker for diagnosing and treating defective acrosome reaction capability in asthenozoospermia patients. Additionally, the level of soluble CD147 in seminal plasma is positively correlated with fertilization rate and pregnancy outcome in infertile couples undergoing in vitro fertilization, suggesting its potential as a predictor in ART outcomes for male infertility.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Biochemistry & Molecular Biology

Metalloproteinases in Ovarian Cancer

Preston Carey et al.

Summary: Proteases, particularly those of the matrix metalloproteinase family, play a crucial role in ovarian cancer progression and metastasis by enhancing migratory ability, ECM breakdown, and tumor support system development. Upregulation of certain proteases influences angiogenesis for tumor growth and development of metastatic implants.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Knockout of CD147 inhibits the proliferation, invasion, and drug resistance of human oral cancer CAL27 cells in Vitro and in Vivo

Siqi Pan et al.

Summary: With the development of modern biomedicine, research has found that the CD147 gene plays a crucial role in tumor development, and CRISPR/Cas9 gene-editing technology can be used to knock out the CD147 gene, reducing the proliferation and invasion abilities of oral cancer cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Interstitial collagenase MMP-1 and EMMPRIN in cell lines and in clinical specimens of cervical squamous cell carcinoma

Nina Solovyeva et al.

Summary: This study elucidated the features of EMN and MMP-1 expression in cervical squamous cell carcinoma, showing that MMP-1 expression is significantly increased in tumor tissue while EMN expression is lower. MMP-1 may serve as a marker of the invasive potential in SCC.

MOLECULAR BIOLOGY REPORTS (2021)

Article Cell Biology

High Glucose and Advanced Glycation End Products Induce CD147-Mediated MMP Activity in Human Adipocytes

Abeer M. Mahmoud et al.

Summary: The study found that high glucose and glycation end products increase CD147 expression and glycosylation in human adipocytes, possibly mediated by NF kappa B and RAGE. This leads to increased activity of MMP2 and MMP9, contributing to cardiovascular complications in diabetes.

CELLS (2021)

Article Anatomy & Morphology

Role of CD147 (EMMPRIN/Basigin) in Tissue Remodeling

Damien Guindolet et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Hepatic CD147 knockout modulates liver steatosis and up-regulates autophagy in high-fat-diet-induced NAFLD mice

Jiaxin Lou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Oncology

CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma

Shi-Jie Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Multidisciplinary Sciences

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Hsiang-chi Tseng et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

Griselda A. Cabral-Pacheco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medical Laboratory Technology

EMMPRIN: A potential biomarker for predicting the presence of obstructive sleep apnea

Haili Sun et al.

CLINICA CHIMICA ACTA (2020)

Article Biochemistry & Molecular Biology

MMP-11 promotes papillary thyroid cell proliferation and invasion via the NF-B pathway

Zhun Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Medicine, Research & Experimental

Structural insights on druggable hotspots in CD147: A bull's eye view

Dhivya Kumar et al.

LIFE SCIENCES (2019)

Article Biochemistry & Molecular Biology

Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin

Ursula Mirastschijski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Oncology

Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes

Shanshan Qi et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

Synergistic effects of TIMP2-418G/C and MMP9-1562C/T variants on the male infertility risk

Shiva Roshankhah et al.

MOLECULAR BIOLOGY REPORTS (2019)

Article Biochemistry & Molecular Biology

CD147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases' pathway

Rezvan Asgari et al.

MOLECULAR BIOLOGY REPORTS (2019)

Article Biochemistry & Molecular Biology

CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis

Wen-Pu Shi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Cyclophilin A and CD147 associate with progression of diabetic nephropathy

Ping-Fang Chiu et al.

FREE RADICAL RESEARCH (2018)

Article Hematology

Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice

Kota Suzuki et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

Agata Jablonska-Trypuc et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis

Xiaoyan Xin et al.

SCIENTIFIC REPORTS (2016)

Article Medical Laboratory Technology

The plasma and peritoneal fluid concentrations of matrix metalloproteinase-9 are elevated in patients with endometriosis

Haiping Liu et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2016)

Article Endocrinology & Metabolism

Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis

Chaoqun Wang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Biochemistry & Molecular Biology

Matrix remodeling by MMPs during wound repair

Maryam G. Rohani et al.

MATRIX BIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Function of CD147 in Atherosclerosis and Atherothrombosis

Cuiping Wang et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2015)

Review Transplantation

CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint

Tomoki Kosugi et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)

Review Biochemistry & Molecular Biology

Bone tissue remodeling and development: Focus on matrix metalloproteinase functions

Katiucia Batista Silva Paiva et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)

Article Biochemistry & Molecular Biology

Enhancement of CD147 on M1 macrophages induces differentiation of Th17 cells in the lung interstitial fibrosis

Jie-jie Geng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Lijuan Xiong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Review Biochemistry & Molecular Biology

Importance of N-Glycosylation on CD147 for Its Biological Functions

Yang Bai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Medicine, Research & Experimental

Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages

Jiatian Cao et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Article Biochemistry & Molecular Biology

Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation

Wan Huang et al.

BIOCHEMICAL JOURNAL (2013)

Article Obstetrics & Gynecology

Identification of CD147 (basigin) as a mediator of trophoblast functions

Cheuk-Lun Lee et al.

HUMAN REPRODUCTION (2013)

Article Biochemistry & Molecular Biology

CD147, CD44, and the Epidermal Growth Factor Receptor (EGFR) Signaling Pathway Cooperate to Regulate Breast Epithelial Cell Invasiveness

G. Daniel Grass et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Obstetrics & Gynecology

Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis

Helena Malvezzi et al.

REPRODUCTIVE SCIENCES (2013)

Review Chemistry, Medicinal

The Role of Matrix Metalloproteinases in Diabetes Mellitus

Costas Tsioufis et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)

Article Cell Biology

Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate

Ryan E. Tyler et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Review Peripheral Vascular Disease

Matrix metalloproteinases in vascular physiology and disease

Suzanne A. Siefert et al.

VASCULAR (2012)

Review Biochemical Research Methods

Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease

Hiromi Fujioka et al.

BIOCHEMISTRY RESEARCH INTERNATIONAL (2012)

Review Biochemistry & Molecular Biology

Physiology and pathophysiology of matrix metalloproteases

T. Klein et al.

AMINO ACIDS (2011)

Review Biochemistry & Molecular Biology

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

Chrisostomi Gialeli et al.

FEBS JOURNAL (2011)

Review Biochemistry & Molecular Biology

Systems biology of JAK-STAT signalling in human malignancies

Julio Vera et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)

Article Cell Biology

Extracellular Matrix Degradation and Remodeling in Development and Disease

Pengfei Lu et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Matrix metalloproteinases: Fold and function of their catalytic domains

Cynthia Tallant et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)

Review Ophthalmology

Direct epithelial-stromal interaction in corneal wound healing: Role of EMMPRIN/CD147 in MMPs induction and beyond

Eric E. Gabison et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2009)

Article Cell Biology

Role of emmprin/CD147 in tissue remodeling

Eric Huet et al.

CONNECTIVE TISSUE RESEARCH (2008)

Review Biochemistry & Molecular Biology

The regulation of matrix metalloproteinases and their inhibitors

Ian A. Clark et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

Review Biochemistry & Molecular Biology

Approaching the degradome in idiopathic pulmonary fibrosis

Annie Pardo et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

Review Cell Biology

Extracellular matrix dynamics in development and regenerative medicine

William P. Daley et al.

JOURNAL OF CELL SCIENCE (2008)

Article Cardiac & Cardiovascular Systems

EMMPRIN mediates beta-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes

Deborah A. Siwik et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)

Review Cell Biology

MMPs in the central nervous system: Where the good guys go bad

Smriti M. Agrawal et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)

Article Medicine, General & Internal

MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis

Ivan O. Rosas et al.

PLOS MEDICINE (2008)

Article Cell Biology

Extracellular matrix: from atomic resolution to ultrastructure

Loannis Vakonakis et al.

CURRENT OPINION IN CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development

Man-il Huh et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2007)

Article Biochemistry & Molecular Biology

AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36

Daphna D. J. Habets et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Review Physiology

Role of matrix metalloproteinases in renal pathophysiologies

J. M. Catania et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)

Review Cell Biology

Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Role of matrix metalloproteinases in delayed cortical responses after stroke

BQ Zhao et al.

NATURE MEDICINE (2006)

Review Immunology

Dealing with the family: CD147 interactions with cyclophilins

V Yurchenko et al.

IMMUNOLOGY (2006)

Article Oncology

Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (I-131) metuximab injection: Clinical phase I/II trials

Zhi-Nan Chen et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

Review Biochemistry & Molecular Biology

Transcriptional regulation of matrix metalloprotease gene expression in health and disease

A Mancini et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2006)

Article Biochemistry & Molecular Biology

Caveolin-1 up-regulates CD 147 glycosylation and the invasive capability of murine hepatocarcinoma cell lines

Li Jia et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

Review Neurosciences

Metalloproteinases: Mediators of pathology and regeneration in the CNS

VW Yong

NATURE REVIEWS NEUROSCIENCE (2005)

Review Cell Biology

Matrix metalloproteinases and angiogenesis

JE Rundhaug

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2005)

Article Cell Biology

Links between CD147 function, glycosylation, and caveolin-1

W Tang et al.

MOLECULAR BIOLOGY OF THE CELL (2004)

Article Biochemistry & Molecular Biology

HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains

JL Jiang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2004)

Article Endocrinology & Metabolism

Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation

SR Lee et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)

Review Oncology

Role of matrix metalloproteinases (MMPs) in colorectal cancer

S Zucker et al.

CANCER AND METASTASIS REVIEWS (2004)

Article Cardiac & Cardiovascular Systems

Circulating matrix metadloproteinase-2 is elevated in patients with congestive heart failure

T Yamazaki et al.

EUROPEAN JOURNAL OF HEART FAILURE (2004)

Review Neurosciences

Mechanisms, challenges and opportunities in stroke

EH Lo et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Review Cardiac & Cardiovascular Systems

Angiogenesis: basic pathophysiology and implications for disease

DC Felmeden et al.

EUROPEAN HEART JOURNAL (2003)

Article Multidisciplinary Sciences

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

FR Zuo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells

JL Jiang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Neurosciences

Metalloproteinases in biology and pathology of the nervous system

VW Yong et al.

NATURE REVIEWS NEUROSCIENCE (2001)

Review Critical Care Medicine

NF-κB activation

E Abraham

CRITICAL CARE MEDICINE (2000)

Article Physiology

TIMP-1,-2,-3, and-4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

M Selman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)