Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 158, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.114083
Keywords
COVID-19; Paulownia tomentosa Steud extract; Antiviral; Antioxydant; Phytocomplex; SARS-CoV-2
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This study investigated the antiviral effect of Paulownia tomentosa extract against SARS-CoV-2 and its antioxidant properties, including respiratory smooth muscle relaxant effects. The results showed that the extract can inhibit viral replication by directly interacting with both the 3-chymotrypsin-like protease and spike protein. Additionally, it has a cyto-protective effect on lung epithelial cells damaged by tert-butyl hydroperoxide. These findings suggest the potential role of Paulownia tomentosa extract in COVID-19 treatment.
COronaVIrus Disease 2019 (COVID-19) is a newly emerging infectious disease that spread across the world, caused by the novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Despite the advancements in science that led to the creation of the vaccine, there is still an urgent need for new antiviral drugs effective against SARS-CoV-2. This study aimed to investigate the antiviral effect of Paulownia tomentosa Steud extract against SARS-CoV-2 and to evaluate its antioxidant properties, including respiratory smooth muscle relaxant effects. Our results showed that P. tomentosa extract can inhibit viral replication by directly interacting with both the 3-chymotrypsin-like protease and spike protein. In addition, the phyto complex does not reduce lung epithelial cell viability and exerts a protective action in those cells damaged by tert-butyl hydroperoxide , a toxic agent able to alter cells' functions via increased oxidative stress. These data suggest the potential role of P. tomentosa extract in COVID-19 treatment, since this extract is able to act both as an antiviral and a cyto-protective agent in vitro.
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