4.2 Article

A Free Fatty Acid Synthetic Agonist Accelerates Wound Healing and Improves Scar Quality in Mice

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges

Julien Ghislain et al.

Summary: This Review summarizes the physiological functions, pharmacology, and clinical studies of G protein-coupled receptors specific for lipid metabolite ligands and discusses the challenges associated with developing therapeutics for type 2 diabetes mellitus. Currently, therapeutic approaches targeting these receptors focus on increasing insulin secretion either by directly acting on beta-cells or indirectly on gastrointestinal enteroendocrine cells that release hormones regulating insulin secretion.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Biochemistry & Molecular Biology

Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

Sarah Mazzotta et al.

Summary: Research shows that Pinocembrin and its derivatives can serve as novel wound healing agents, enhancing wound healing effects by interacting with GPR120. These compounds exert their activity by sharing the same binding pocket with the known GPR120 agonist.

BIOORGANIC CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet-Induced Inflammation

Natalia Ferreira Mendes et al.

Summary: Under high-fat feeding, the hypothalamus undergoes pro-inflammatory signaling activation, with recent data revealing microglial heterogeneity throughout the brain. The roles of microglial subpopulations in hypothalamic inflammation have been studied, but how each subset functions in response to inflammatory stimuli remains unclear. Novel experimental models have been developed to study the characteristics and roles of microglial subtypes, and transcriptomic data is being used to identify changes in hypothalamic microglial signature under short-term and long-term high-fat feeding.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

A method to analyze the influence of mechanical strain on dermal collagen morphologies

Maximilian Witte et al.

Summary: This study reveals the importance of collagen fibers and their orientation in the mechanical behavior of soft biological tissue such as skin, correlating mechanical properties with collagen fiber network morphologies using the newly introduced Fiber Image Network Evaluation algorithm. The alignment of fiber families under strain occurs in two steps, demonstrating that the maximum alignment of the collagen fiber network is determined by the largest strain.

SCIENTIFIC REPORTS (2021)

Article Cell & Tissue Engineering

Mechanical Roles in Formation of Oriented Collagen Fibers

Jiexiang Lin et al.

TISSUE ENGINEERING PART B-REVIEWS (2020)

Review Cell Biology

The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing

Kavya L. Singampalli et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms

Daiane F. Engel et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

Griselda A. Cabral-Pacheco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Endocrinology & Metabolism

Targeting FFA1 and FFA4 receptors in cancer-induced cachexia

Raquel D. S. Freitas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Article Nursing

Topical Topiramate Improves Wound Healing in an Animal Model of Hyperglycemia

Carlos Poblete Jara et al.

BIOLOGICAL RESEARCH FOR NURSING (2019)

Editorial Material Multidisciplinary Sciences

The secrets of healing without scars

Cassandra Willyard

NATURE (2018)

Editorial Material Multidisciplinary Sciences

SUPERPOWERED SKIN

Julie Gould

NATURE (2018)

Article Medicine, Research & Experimental

GPR40 receptor activation promotes tight junction assembly in airway epithelial cells via AMPK-dependent mechanisms

Aekkacha Moonwiriyakit et al.

TISSUE BARRIERS (2018)

Article Rheumatology

GPR120 is an important inflammatory regulator in the development of osteoarthritis

Yuanfeng Chen et al.

ARTHRITIS RESEARCH & THERAPY (2018)

Article Biochemistry & Molecular Biology

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Jun Lu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Jun Lu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Cell Biology

A novel anti-inflammatory role of GPR120 in intestinal epithelial cells

Arivarasu N. Anbazhagan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Article Nursing

Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120

Eva L. Arantes et al.

BIOLOGICAL RESEARCH FOR NURSING (2016)

Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

Article Endocrinology & Metabolism

GPR 120: The Potential Target for Obesity Treatment

Peter A. Tanagho et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2016)

Review Dermatology

Cellular and molecular mechanisms of repair in acute and chronic wound healing

P. Martin et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

Article Multidisciplinary Sciences

Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy

Ming Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Medicine, Research & Experimental

Wound Healing and Skin Regeneration

Makoto Takeo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Biochemistry & Molecular Biology

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Da Young Oh et al.

NATURE MEDICINE (2014)

Review Endocrinology & Metabolism

Regulation of energy homeostasis via GPR120

Atsuhiko Ichimura et al.

FRONTIERS IN ENDOCRINOLOGY (2014)

Review Dermatology

Regenerative Wound Healing: The Role of Interleukin-10

Alice King et al.

ADVANCES IN WOUND CARE (2014)

Article Biochemical Research Methods

The mouse excisional wound splinting model, including applications for stem cell transplantation

Xusheng Wang et al.

NATURE PROTOCOLS (2013)

Review Dermatology

Growth Factor-Extracellular Matrix Interactions Regulate Wound Repair

Traci A. Wilgus

ADVANCES IN WOUND CARE (2012)

Article Pharmacology & Pharmacy

Differential Signaling by Splice Variants of the Human Free Fatty Acid Receptor GPR120

Sarah-Jane Watson et al.

MOLECULAR PHARMACOLOGY (2012)

Review Chemistry, Medicinal

Free Fatty Acid Receptors FFAR1 and GPR120 as Novel Therapeutic Targets for Metabolic Disorders

Takafumi Hara et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

Article Pathology

Accelerated wound closure in mice deficient for interleukin-10

Sabine A. Eming et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

Article Biochemistry & Molecular Biology

The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing

D. K. Covington et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2006)

Article Biochemistry & Molecular Biology

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

A Hirasawa et al.

NATURE MEDICINE (2005)