4.6 Review

Role of ferroptosis inhibitors in the management of diabetes

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells

Xinhao Zhang et al.

Summary: Acrolein, a common food and environmental pollutant, induces ferroptosis in pancreatic beta cells, leading to dysfunction. Endoplasmic reticulum stress plays a critical role in acrolein-induced ferroptosis. Resveratrol can alleviate ER stress and protect pancreatic cells from acrolein-induced damage.

TOXICOLOGY (2022)

Review Endocrinology & Metabolism

Ferroptosis and ferritinophagy in diabetes complications

Jiahui He et al.

Summary: This review systematically explores the roles and regulatory mechanisms of ferroptosis and ferritinophagy in diabetes complications and highlights their potential therapeutic value. However, further research is needed to fully understand their molecular mechanisms and pathophysiological processes involved.

MOLECULAR METABOLISM (2022)

Review Endocrinology & Metabolism

Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications

Xi-Ding Yang et al.

Summary: This review summarizes the role and regulatory mechanisms of ferroptosis in diabetes and its complications, as well as the inhibitors of ferroptosis in diabetes and diabetic complications. Understanding the regulation of ferroptosis and developing drugs targeting ferroptosis may provide new treatment strategies for patients with diabetes.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Cell Biology

Never-in-Mitosis A-Related Kinase 8 (NEK8) Regulates Adipogenesis, Glucose Homeostasis, and Obesity

Yan-Jun Wang et al.

Summary: NEK8 plays a critical role in adipocyte proliferation and is associated with obesity related to type 2 diabetes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Article Chemistry, Multidisciplinary

NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells

Chun-shuang Ma et al.

Summary: The study demonstrates the crucial role of NRF2 in mediating resistance to EGFR-TKIs by regulating the expression of GPX4 and SOD2. Targeting the NRF2-GPX4/SOD2 pathway may be a potential strategy for overcoming resistance to EGFR-TKIs, providing a novel approach in treating NSCLC.

ACTA PHARMACOLOGICA SINICA (2021)

Article Multidisciplinary Sciences

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

Yue Wang et al.

Summary: The study demonstrated that quercetin (QCT), a natural flavonoid, inhibited ferroptosis in renal proximal tubular epithelial cells by reducing lipid ROS levels and increasing glutathione (GSH) levels. QCT also ameliorated acute kidney injury induced by ischemia-reperfusion (I/R) or folic acid (FA). Furthermore, RNA-sequence analysis revealed ATF3 as a key factor in QCT's inhibition of ferroptosis. Additionally, QCT inhibited the recruitment of pro-inflammatory macrophages in AKI.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Clinical Neurology

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis

Yasir Abdul et al.

Summary: This study found that iron chelation therapy with deferoxamine can prevent vasoregression and improve functional outcomes in diabetic rats after stroke, but it does not have a significant effect in non-diabetic rats. Furthermore, iron chelation may inhibit ferroptosis and provide a novel therapeutic strategy for preventing post-stroke cognitive impairment in diabetes.

TRANSLATIONAL STROKE RESEARCH (2021)

Article Anesthesiology

Inhibition of ferroptosis-like cell death attenuates neuropathic pain reactions induced by peripheral nerve injury in rats

Yue Guo et al.

Summary: The study discovered that ferroptosis plays a crucial role in neuropathic pain induced by peripheral nerve injury, and inhibiting ferroptosis with liproxstatin-1 could alleviate hypersensitivity, suggesting a potential therapeutic target for neuropathic pain.

EUROPEAN JOURNAL OF PAIN (2021)

Article Oncology

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

Jingfa Zhang et al.

Summary: The increased permeability of retinal capillary endothelial cells is a key feature in the progression of diabetic retinopathy. Mechanistic insights into the involvement of TRIM46 and GPX4 in regulating ferroptosis of HRCECs provide potential therapeutic targets for the treatment of DR.

EXPERIMENTAL CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells

Caijun Zhao et al.

Summary: Acute cadmium exposure can induce renal injury through ferroptosis, regulated by factors such as ER stress, autophagy, and ferritinophagy. Iron dysregulation and MitoROS activation are also involved in the process.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Endocrinology & Metabolism

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

Er-Fei Luo et al.

Summary: Ferroptosis is involved in endothelial dysfunction caused by diabetes, with activation of the p53-xCT-GSH axis playing a crucial role in endothelial cell ferroptosis and dysfunction.

WORLD JOURNAL OF DIABETES (2021)

Article Biochemistry & Molecular Biology

NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells

Magdalena Gryzik et al.

Summary: This study found that NCOA4 deficiency increases ferritin levels and makes cells more resistant to erastin but more sensitive to RSL3. Erastin promotes ferritinophagy, increasing free iron, lipid peroxidation, and sensitivity to ferroptosis, while RSL3 mechanism is independent of ferritin degradation process. The release of ferritin-iron in the execution of ferroptosis seems to depend on the inducing compound, its target, and downstream pathway of cell death activation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Biotechnology & Applied Microbiology

The effect of platelet-rich plasma-fibrin glue dressing in combination with oral vitamin E and C for treatment of non-healing diabetic foot ulcers: a randomized, double-blind, parallel-group, clinical trial

Amir Yarahmadi et al.

Summary: This study found that the use of PRP-FG dressing along with oral vitamin E and C can significantly accelerate wound healing and reduce oxidative stress markers in patients with non-healing diabetic foot ulcers.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

Editorial Material Biochemistry & Molecular Biology

A roadmap to creating ferroptosis-based medicines

Kamyar Hadian et al.

Summary: Ferroptosis is a regulated form of non-apoptotic cell death that requires specific reagents for detection in human and animal tissues to enable the development of ferroptosis-based medicines for various diseases.

NATURE CHEMICAL BIOLOGY (2021)

Article Cell Biology

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

Seonghun Kim et al.

Summary: The study evaluated the role of ferroptosis in diabetes-induced tubular injury. Results indicated that ferroptosis triggers kidney cell death by affecting glutathione concentration and lipid peroxidation, and the use of ferroptosis inhibitors can alleviate this process.

CELL DEATH & DISEASE (2021)

Article Endocrinology & Metabolism

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

Xiaomeng Feng et al.

Summary: The study found that ferroptosis aggravated diabetic nephropathy and damaged renal tubules in db/db mice through the HIF-1 alpha/HO-1 pathway.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Biotechnology & Applied Microbiology

Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis

Zhaoliang Zhu et al.

Summary: The study demonstrates that knockdown of circ-PSEN1 can alleviate HG-induced ferroptosis in ARPE19 cells via the miR-200b-3p/CFL2 axis, providing a novel therapeutic strategy for the treatment of DR.

BIOENGINEERED (2021)

Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Huan He et al.

Summary: The mechanism of Doxorubicin-induced cardiotoxicity is complex, involving multiple cell death forms, with clinical intervention effect not ideal. By inhibiting iron accumulation, oxidative stress, and abnormal lipid metabolism, it is possible to alleviate Doxorubicin-induced cardiotoxicity-induced ferroptosis and protect the myocardium. Epigallocatechin-3-gallate is a potential candidate phytochemical for combating Doxorubicin-induced cardiotoxicity.

REDOX BIOLOGY (2021)

Article Cell Biology

Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells

Karan Naresh Amin et al.

Summary: The endoplasmic reticulum is crucial for protein folding and trafficking, and its disruption can lead to cell apoptosis and diseases. Nrf2 is a key transcription factor for cell protection and detoxification mechanisms. Rosolic acid was shown to activate Nrf2, reduce ER stress-induced endothelial apoptosis, and attenuate ER stress in endothelial cells.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Correction Cell Biology

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions (vol 12, 160, 2021)

Seonghun Kim et al.

Summary: A correction for this paper has been published, please refer to the link provided.

CELL DEATH & DISEASE (2021)

Article Endocrinology & Metabolism

Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound

Shuangwen Li et al.

Summary: Ferroptosis plays a crucial role in diabetic wound healing, with inhibition of ferroptosis reducing inflammation and promoting wound healing. Restraint of ferroptosis leads to restoration of the PI3K/AKT signal pathway in diabetic wounds, ultimately mitigating ferroptosis and enhancing wound healing.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

Article Endocrinology & Metabolism

Role of ferritin and oxidative stress index in gestational diabetes mellitus

Surabhi Gautam et al.

Summary: The study investigated the impact of pre-pregnancy BMI on serum ferritin and oxidative stress levels in GDM patients, leading to higher blood glucose levels. Serum ferritin and oxidative stress were positively correlated with 2 h blood glucose and HbA1c, potentially causing pancreatic beta-cell injury and death. Serum ferritin and OSI could be potential therapeutic and monitoring targets for overweight/obese pregnant females, especially those with GDM.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

Article Biochemistry & Molecular Biology

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

Bastian Kruemmel et al.

Summary: Pro-inflammatory cytokines play a crucial role in beta-cell destruction in type 1 diabetes mellitus, while the involvement of ferroptosis in the pathogenesis of the disease has not been clearly defined. The antioxidative enzyme GPx4 is predominantly expressed in beta-cells, and its overexpression as well as the ferroptosis inhibitor ferrostatin-1 can effectively attenuate beta-cell death. Nitric oxide produced during pro-inflammatory cytokine action prevents the induction of ferroptosis, favoring apoptosis as the primary cell death mechanism in beta-cells.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Article Geriatrics & Gerontology

Dysregulation of Nrf2 redox pathway in macrophages under diabetic microenvironment

Goutham Ganesh et al.

Summary: In this study, aberrations in Nrf2 signaling in macrophages under a hyperglycemic microenvironment were characterized, and the Nrf2 activator pterostilbene was found to improve these abnormalities and restore some related indicators.

EXPERIMENTAL GERONTOLOGY (2021)

Article Plant Sciences

Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease

Ravichandran Jayasuriya et al.

Summary: Nrf2 activators show promising effects in resisting various liver diseases induced by different toxicants in preclinical experiments and in vitro studies by regulating cell proliferation and apoptosis as well as an antioxidant defense mechanism.

PHYTOMEDICINE (2021)

Article Cell Biology

GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

Qian Hu et al.

Summary: Research has shown that hematopoietic stem cells and progenitor cells lacking Gpx4 can undergo ferroptosis in vitro, but can be rescued by vitamin E.

CELL DEATH & DISEASE (2021)

Review Endocrinology & Metabolism

Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

Wenxin Sha et al.

Summary: Ferroptosis is a novel form of cell death characterized by iron-dependent lipid peroxide accumulation and inadequate GPX4. It is ubiquitous in physiological and pathological processes, playing a role in the pathogenesis of diabetes.

JOURNAL OF DIABETES RESEARCH (2021)

Article Biochemistry & Molecular Biology

Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy

Shuangwen Li et al.

Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Chemistry, Multidisciplinary

Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications

Huizhen Zheng et al.

Summary: The combination of nanotechnology with ferroptosis for the treatment of severe diseases has attracted substantial research interest. However, differentiating nanoparticle-induced ferroptosis from other types of cell deaths, elucidating detailed mechanisms, and exploring the key properties of nanoparticles are challenging. Understanding the molecular events and physicochemical properties of nano-inducers involved in ferroptosis is crucial for designing effective nanomaterials for deliberate modulation of ferroptosis.

NANOSCALE (2021)

Article Cell Biology

Crosstalk between endoplasmic reticulum stress and oxidative stress in the progression of diabetic nephropathy

Paul Victor et al.

Summary: The study investigates the crosstalk between endoplasmic reticulum stress and oxidative stress, and their significant contribution to the onset and progression of diabetic nephropathy, suggesting potential therapeutic targets for alleviating complications associated with this metabolic disturbance.

CELL STRESS & CHAPERONES (2021)

Article Cell Biology

Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4

Bao-You Fan et al.

Summary: Our previous study highlighted the significance of ferroptosis in spinal cord injury. We established an oligodendrocyte model induced by RSL-3 inhibition of GPX4, which increased ROS levels and malondialdehyde concentrations. Additionally, we found that Liproxstatin-1 was a potent inhibitor of ferroptosis in oligodendrocytes, suggesting its potential as a treatment for CNS diseases.

NEURAL REGENERATION RESEARCH (2021)

Review Food Science & Technology

Mechanism and intervention measures of iron side effects on the intestine

Xiao Qi et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Editorial Material Biochemistry & Molecular Biology

Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis

Kamyar Hadian

BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

Wenyuan Li et al.

DNA AND CELL BIOLOGY (2020)

Article Engineering, Environmental

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

Sen Wei et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

Review Endocrinology & Metabolism

Iron metabolism and type 2 diabetes mellitus: A meta-analysis and systematic review

Jingfang Liu et al.

JOURNAL OF DIABETES INVESTIGATION (2020)

Article Chemistry, Analytical

Method for Structural Determination of Lipid-Derived Radicals

Yuta Matsuoka et al.

ANALYTICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Giovanni Miotto et al.

REDOX BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Identification of Frataxin as a regulator of ferroptosis

Jing Du et al.

REDOX BIOLOGY (2020)

Article Biochemistry & Molecular Biology

System χc- overexpression prevents 2-deoxy-D-ribose-induced β-cell damage

Soyeon Yoo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Pharmacology & Pharmacy

The Mechanism of Ferroptosis and Applications in Tumor Treatment

Xinyue Lin et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Endocrinology & Metabolism

The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis

Yi Zhou

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Article Biochemistry & Molecular Biology

Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion

Yixin Xu et al.

FASEB JOURNAL (2020)

Article Cell Biology

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

Zhuanzhuan Qiang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Article Cell Biology

Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers

Rajan Teena et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Review Cell Biology

Oxidative Damage and Antioxidant Defense in Ferroptosis

Feimei Kuang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Pharmacology & Pharmacy

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

Yue Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Medicine, Research & Experimental

Novel insights into ferroptosis: Implications for age-related diseases

Ren-Peng Zhou et al.

THERANOSTICS (2020)

Article Tropical Medicine

Gymnema montanum improves endothelial function via inhibition of endoplasmic reticulum stress by activating Nrf2 signaling

Dornadula Sireesh et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2020)

Article Clinical Neurology

Diagnosis of peripheral neuropathy

Helmar C. Lehmann et al.

NEUROLOGICAL RESEARCH AND PRACTICE (2020)

Review Biochemistry & Molecular Biology

The interaction between ferroptosis and lipid metabolism in cancer

Dingshan Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Medicine, General & Internal

Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis

Riccardo Cheloni et al.

BMJ OPEN (2019)

Review Physiology

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

Pengxu Lei et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Endocrinology & Metabolism

Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction

Tingting Shu et al.

ENDOCRINE CONNECTIONS (2019)

Article Biochemistry & Molecular Biology

Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin

Somanathapura K. NaveenKumar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Article Biochemistry & Molecular Biology

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

Melania Guerrero-Hue et al.

FASEB JOURNAL (2019)

Article Medicine, General & Internal

Gestational diabetes mellitus

H. David McIntyre et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Article Cell Biology

Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients

Harshi Prasadini Gunawardena et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Review Nutrition & Dietetics

Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases

Rattiyaporn Kanlaya et al.

ADVANCES IN NUTRITION (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Multidisciplinary Sciences

Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress

Hye Kyoung Sung et al.

SCIENTIFIC REPORTS (2019)

Editorial Material Cell Biology

Antioxidants and Prooxidants: Effects on Health and Aging

Marcio Carocho et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

Article Cell Biology

Ferroptosis-inducing agents compromise in vitro human islet viability and function

Antonio Bruni et al.

CELL DEATH & DISEASE (2018)

Review Pharmacology & Pharmacy

The Role of Ferroptosis in Cancer Development and Treatment Response

Bin Lu et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

Michael John Kerins et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Biochemistry & Molecular Biology

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

Daiha Shin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Letter Dermatology

Reduction in human hair graying by sterubin, an active flavonoid of Eriodictyon angustifolium

Nobuhiko Taguchi et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2018)

Article Urology & Nephrology

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI

Diego Martin-Sanchez et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Chemistry, Medicinal

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

Biswanath Dinda et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Pharmacology & Pharmacy

Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells

Pachamuthu Vanitha et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

Weixia Sun et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Cell Biology

Oxidative Stress in Pancreatic Beta Cell Regeneration

Jingjing Wang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Endocrinology & Metabolism

Lipids: A Suitable Therapeutic Target in Diabetic Neuropathy?

M. C. Perez-Matos et al.

JOURNAL OF DIABETES RESEARCH (2017)

Article Endocrinology & Metabolism

Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression

Xuhua Mao et al.

ENDOCRINE CONNECTIONS (2017)

Review Biochemistry & Molecular Biology

Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells

Sigurd Lenzen

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Article Oncology

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

Shan Zhu et al.

CANCER RESEARCH (2017)

Review Neurosciences

Melatonin: Pharmacology, Functions and Therapeutic Benefits

Sylvie Tordjman et al.

CURRENT NEUROPHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Lipid peroxidation in cell death

Michael M. Gaschler et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Nutrition & Dietetics

Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)

Neha Atulkumar Singh et al.

NUTRITION JOURNAL (2016)

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Article Biochemistry & Molecular Biology

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

Yangchun Xie et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Chemistry, Medicinal

Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2

Bhakkiyalakshmi Elango et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2016)

Article Cell Biology

Roles of Fe-S proteins: from cofactor synthesis to iron homeostasis to protein synthesis

Debkumar Pain et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)

Article Ophthalmology

Early changes in system xc- and glutathione in the retina of diabetic rats

Raul Carpi-Santos et al.

EXPERIMENTAL EYE RESEARCH (2016)

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemistry & Molecular Biology

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

Alexander R. Bogdan et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Cell Biology

Ferrootosis: Death by Lipid Peroxidation

Wan Seok Yang et al.

TRENDS IN CELL BIOLOGY (2016)

Review Endocrinology & Metabolism

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes

Jose Manuel Fernandez-Real et al.

DIABETES CARE (2015)

Article Biochemistry & Molecular Biology

HSPB1 as a novel regulator of ferroptotic cancer cell death

X. Sun et al.

ONCOGENE (2015)

Review Pharmacology & Pharmacy

The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes

Elango Bhakkiyalakshmi et al.

PHARMACOLOGICAL RESEARCH (2015)

Article Pharmacology & Pharmacy

Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2

Elango Bhakkiyalakshmi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Endocrinology & Metabolism

Diagnosis and Classification of Diabetes Mellitus

DIABETES CARE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Article Neurosciences

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

Saif Ahmad et al.

NEUROTOXICOLOGY (2014)

Article Multidisciplinary Sciences

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Endocrinology & Metabolism

Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice

Yu Fu et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2014)

Review Neurosciences

A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress

Namrata Chaudhari et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Pharmacology & Pharmacy

Heat Shock Protein 70 Is Necessary to Improve Mitochondrial Bioenergetics and Reverse Diabetic Sensory Neuropathy following KU-32 Therapy

Jiacheng Ma et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

Article Biochemistry & Molecular Biology

High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications

Saeed Yadranji Aghdam et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Review Biochemistry & Molecular Biology

Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy

Yan-Ming Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Pharmacology & Pharmacy

Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells

G. Bardy et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Neurosciences

Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy

Sergey Lupachyk et al.

EXPERIMENTAL NEUROLOGY (2013)

Article Chemistry, Multidisciplinary

A highly selective turn-on fluorescent probe for iron(II) to visualize labile iron in living cells

Tasuku Hirayama et al.

CHEMICAL SCIENCE (2013)

Review Immunology

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

Ryan W. Grant et al.

FRONTIERS IN IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and Type 2 Diabetes

Sung Hoon Back et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Review Pharmacology & Pharmacy

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

Richard J. Bridges et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress, obesity and diabetes

Miriam Cnop et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Review Pharmacology & Pharmacy

Heme oxygenase-1, oxidation, inflammation, and atherosclerosis

Jesus A. Araujo et al.

FRONTIERS IN PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Mustafa Ulas et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2011)

Review Biochemistry & Molecular Biology

The role of iron in type 2 diabetes in humans

Swapnil N. Rajpathak et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Review Endocrinology & Metabolism

Standards of Medical Care in Diabetes-2009

DIABETES CARE (2009)

Article Pharmacology & Pharmacy

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

Leah R. Hanson et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Biochemistry & Molecular Biology

Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2

Prasad N. Paradkar et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Endocrinology & Metabolism

Pancreatic β-cells express hepcidin, an iron-uptake regulatory peptide

Hasan Kulaksiz et al.

JOURNAL OF ENDOCRINOLOGY (2008)

Review Endocrinology & Metabolism

Melatonin, endocrine pancreas and diabetes

Elmar Peschke

JOURNAL OF PINEAL RESEARCH (2008)

Article Multidisciplinary Sciences

Insulin gene mutations as a cause of permanent neonatal diabetes

Julie Stoy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

Nicholas Yagoda et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases

Joshua D. Deschamps et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Medicine, General & Internal

A protective role for heme oxygenase-1 in INS-1 cells and rat islets that are exposed to high glucose conditions

Kyu Chang Won et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2006)

Article Pharmacology & Pharmacy

Vitamin E inhibits hemolysis induced by hemin as a membrane stabilizer

F Wang et al.

BIOCHEMICAL PHARMACOLOGY (2006)

Article Endocrinology & Metabolism

Mechanisms of β-cell death in type 2 diabetes

MY Donath et al.

DIABETES (2005)

Article Gastroenterology & Hepatology

Iron and insulin resistance

S Fargion et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2005)

Review Multidisciplinary Sciences

β-cell death during progression to diabetes

D Mathis et al.

NATURE (2001)

Review Pharmacology & Pharmacy

Rosiglitazone in the treatment of type 2 diabetes mellitus: A critical review

JM Malinowski et al.

CLINICAL THERAPEUTICS (2000)