4.4 Editorial Material

Neddylation-CRLs regulate the functions of Treg immune cells

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness

Di Wu et al.

Summary: This study reveals that the absence of Rbx1, a component of Cullin-RING ligases, in regulatory T cells leads to a severe inflammatory disease. The Ube2m-Rbx1 axis is specifically required for intrinsic regulatory processes in Treg cells.

NATURE COMMUNICATIONS (2022)

Article Microbiology

RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

Chenhui Li et al.

Summary: The neddylation modification is essential for the appropriate activation of the cGAS-STING signaling pathway, affecting the induction of type I interferon and proinflammatory cytokines. The Ube2m-Rnf111 neddylation axis plays a vital role in promoting the activity of the cGAS-STING pathway and neddylation modification is highlighted as important in antiviral defense.

PLOS PATHOGENS (2021)

Article Pathology

SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses

Nathan D. Mathewson et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

Article Pharmacology & Pharmacy

Cullin-RING Ligases as Attractive Anti-cancer Targets

Yongchao Zhao et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Article Biochemistry & Molecular Biology

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

Danny T. Huang et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy et al.

NATURE (2009)

Article Multidisciplinary Sciences

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27

Mingjia Tan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Control of regulatory T cell development by the transcription factor Foxp3

S Hori et al.

SCIENCE (2003)

Review Biochemistry & Molecular Biology

SAG/ROC/Rbx/Hrt, a zinc RING finger gene family:: Molecular cloning, biochemical properties, and biological functions

Y Sun et al.

ANTIOXIDANTS & REDOX SIGNALING (2001)