Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1868, Issue 12, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2022.166555
Keywords
Mechanotransduction; Mechanical stress; Matrix stiffness; Cancer invasion; Metastasis; Tumor microenvironment
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Mechanical features of cancer cells play a crucial role in tumor development and progression, with mechanosensory proteins potentially mediating oncogenic signaling and response to chemotherapy. Studying changes in tumor microenvironment and matrix rigidity can offer new anti-cancer strategies.
Mechanical features of cancer cells emerge as a distinct trait during development and progression of solid tumors. Herein, we discuss recent key findings regarding the impact of various types of mechanical stresses on cancer cell properties. Data suggest that different mechanical forces, alterations of matrix rigidity and tumor microenvironment facilitate cancer hallmarks, especially invasion and metastasis. Moreover, a subset of mechanosensory proteins are responsible for mediating mechanically induced oncogenic signaling and response to chemotherapy. Delineating cancer dynamics and decoding of respective signal transduction mechanisms will provide new therapeutic strategies against solid tumors in the future.
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