Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies

Article Cell Biology

TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease

Lijie Gu et al.

Summary: This study demonstrates that TLR13 is involved in CKD-induced insulin resistance in muscle, and targeting TLR13 in conditions of catabolism may improve insulin sensitivity and prevent muscle atrophy.

CELL PROLIFERATION (2022)

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Article Transplantation

Inflammation and physical dysfunction: responses to moderate intensity exercise in chronic kidney disease

Emma L. Watson et al.

Summary: People with chronic kidney disease experience skeletal muscle wasting, reduced levels of physical function and performance, and chronic systemic inflammation. In this study, the association between inflammation and physical function or performance in CKD patients was investigated. The study found that moderate intensity exercise can attenuate intramuscular inflammation in CKD patients, but is unable to reduce systemic inflammation. Further research is needed to fully understand the relationship between inflammation and physical function in CKD.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Article Genetics & Heredity

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

Cecile Ribot et al.

Summary: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder characterized by progressive weakness and degeneration of specific muscles. Previous studies have shown that the ubiquitin-proteasome system (UPS) is deregulated in OPMD, contributing to the disease pathogenesis. In this Drosophila model of OPMD, increased UPS activity leads to muscle protein degradation and atrophy. Inhibitors of proteasome activity, such as MG132, show potential as a pharmacological approach for OPMD treatment, improving muscle function. This study highlights the importance of UPS deregulation in OPMD and suggests proteasome inhibitors as potential therapeutic options.

PLOS GENETICS (2022)

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Review Geriatrics & Gerontology

Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis

Fanny Petermann-Rocha et al.

Summary: The diagnosis and prevalence of sarcopenia vary considerably, and future studies should follow current guidelines to facilitate comparison of results across different studies and populations globally.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

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Article Biochemistry & Molecular Biology

SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation

Wei Wang et al.

Summary: The study found that SKP-SC-EVs can alleviate denervated muscle atrophy by inhibiting oxidative stress and inflammation, promoting proliferation and differentiation of myoblasts, improving muscle blood perfusion, and reducing mitochondrial vacuolar degeneration and autophagy.

ANTIOXIDANTS (2022)

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Review Pharmacology & Pharmacy

Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy

Wei Wang et al.

Summary: Pathophysiological changes of skeletal muscle can cause muscle atrophy and dysfunction, greatly affecting quality of life. Extracellular vesicles (EVs) are involved in the pathophysiological processes of skeletal muscle. EVs play a role in skeletal muscle growth, regeneration, and atrophy by delivering bioactive molecules. EVs have potential as biomarkers and therapeutic carriers for skeletal muscle diseases.

BIOCHEMICAL PHARMACOLOGY (2022)

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Editorial Material Biochemistry & Molecular Biology

Skeletal muscle atrophy

Leslie M. Baehr et al.

CELL (2022)

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Review Biochemistry & Molecular Biology

Chronic Kidney Disease and Gut Microbiota: What Is Their Connection in Early Life?

Chien-Ning Hsu et al.

Summary: The gut-kidney interaction and gut microbiota-targeted therapies have gained increasing attention in the research of chronic kidney disease (CKD). Understanding the impact of early-life gut microbiome on CKD and the development of early interventions are crucial for reducing CKD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications-A Narrative Review

Tsai-Chin Cheng et al.

Summary: This narrative review discusses the factors and treatment strategies related to muscle wasting in patients with chronic kidney disease, including muscle protein metabolism, muscle cell regeneration, insulin-like growth factor 1 and myostatin signaling pathways, as well as the role of microRNA and gut microbiota in muscle mass and myogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Medicinal

Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1/FoxO1

Ruiting Wang et al.

Summary: Chronic kidney disease (CKD) is often accompanied by muscle atrophy, and the application of resveratrol can improve renal function, reduce renal fibrosis, and alleviate muscle atrophy. SIRT1 plays a crucial role in linking renal disease and muscle atrophy, possibly through regulating FoxO1. Therefore, resveratrol and other SIRT1 agonists have great therapeutic potential for treating CKD and its related muscle atrophy.

PHYTOTHERAPY RESEARCH (2022)

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Article Urology & Nephrology

Effects of veverimer on serum bicarbonate and physical function in women with chronic kidney disease and metabolic acidosis: a subgroup analysis from a randomised, controlled trial

Vandana S. Mathur et al.

Summary: The study found that veverimer is effective in treating metabolic acidosis in women with CKD and significantly improves their physical function.

BMC NEPHROLOGY (2022)

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Review Nutrition & Dietetics

The Effect of Nutrition and Exercise on Body Composition, Exercise Capacity, and Physical Functioning in Advanced CKD Patients

Maryam Ekramzadeh et al.

Summary: Patients with CKD commonly have reduced physical activity and muscle function. Nutritional supplements and exercise training can improve muscle mass and exercise capacity, but it is uncertain whether they can reduce morbidity or mortality rates.

NUTRIENTS (2022)

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Article Food Science & Technology

Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells

Sota Todoriki et al.

Summary: Uremic sarcopenia is a serious clinical problem associated with physical disability and increased morbidity and mortality. Methylglyoxal (MG), a uremic toxin, accumulates in patients with chronic kidney disease (CKD) and is related to the pathology of uremic sarcopenia. The mechanisms of MG-induced muscle atrophy in myoblast cells involve metabolic flow change and mitochondrial injury.

TOXINS (2022)

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Article Sport Sciences

Effects of Different Types of Exercise on Kidney Diseases

Hamid Arazi et al.

Summary: Exercise has positive effects on kidney function and is particularly important for patients with chronic kidney disease. It can improve blood pressure control, sleep quality, physical function, and reduce anxiety and depression. However, caution should be exercised to avoid overexertion and dehydration.

SPORTS (2022)

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Review Biochemistry & Molecular Biology

Inhibition of myostatin and related signaling pathways for the treatment of muscle atrophy in motor neuron diseases

Elena Abati et al.

Summary: Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. Inhibition of myostatin has shown potential in enhancing muscle growth and reducing muscle atrophy, making it a promising target for the treatment of motor neuron diseases. This review aims to describe the role of myostatin in these diseases, summarize preclinical and clinical studies of myostatin inhibitors, and discuss the promises and pitfalls of using these inhibitors in human settings, to aid the development of future clinical trials.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Physiology

Changes of Gene Expression Patterns of Muscle Pathophysiology-Related Transcription Factors During Denervated Muscle Atrophy

Xiaoming Yang et al.

Summary: Peripheral nerve injury can cause skeletal muscle atrophy and dysfunction. Transcription factors play a key role in this process. The current study identified differentially expressed transcription factors that are mainly involved in immune response, providing insights into the regulatory mechanisms and potential therapeutic targets for muscle atrophy following peripheral nerve injury.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Physiology

Resistance Exercise in People With Stage-3 Chronic Kidney Disease: Effects of Training Frequency (Weekly Volume) on Measures of Muscle Wasting and Function

Louise J. Geneen et al.

Summary: The study investigated the effects of resistance training (RT) frequency on muscle wasting and function in non-dialysis dependent CKD patients. The results showed that performing RT once per week was as effective as thrice weekly RT in improving strength, physical function, and reducing uraemic symptoms, although there were differences in muscle anatomical adaptations between the two frequencies.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Endocrinology & Metabolism

Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies

Yuntian Shen et al.

Summary: Diabetes mellitus is a chronic disease that can lead to complications such as kidney disease, cardiovascular disease, neuropathy, and skeletal muscle atrophy. Understanding the molecular regulatory mechanisms of diabetic muscular atrophy is important in developing new treatment strategies.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Pharmacology & Pharmacy

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function

Yan Yan et al.

Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Urology & Nephrology

Sarcopenia and Frailty: Challenges in Mainstream Nephrology Practice

Limy Wong et al.

Summary: Sarcopenia and frailty are common in patients with chronic kidney disease, characterized by muscle mass loss, decreased function, and multi-system impairment. Exercise training and nutritional supplementation are key interventions to maintain skeletal muscle mass and strength in these patients.

KIDNEY INTERNATIONAL REPORTS (2021)

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Review Urology & Nephrology

Metabolic Acidosis in Patients with CKD: Epidemiology, Pathogenesis, and Treatment

Marcin Adamczak et al.

Summary: Metabolic acidosis in CKD patients is common and can contribute to disease progression and various complications, worsening patient prognosis. Currently, sodium bicarbonate is the main treatment for metabolic acidosis. The role of the new drug veverimer in metabolic acidosis therapy requires further study.

KIDNEY DISEASES (2021)

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Review Transplantation

Myostatin and muscle atrophy during chronic kidney disease

Stanislas Bataille et al.

Summary: The Mstn pathway is implicated in muscle wasting in CKD and may serve as a potential biomarker in dialysis patients. However, more research is needed to validate its application in this field.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Article Plant Sciences

Dojuksan ameliorates tubulointerstitial fibrosis through irisin-mediated muscle-kidney crosstalk

Songling Jiang et al.

Summary: The study demonstrates that Dojuksan may prevent the progression of kidney fibrosis through irisin-mediated muscle-kidney crosstalk, showing greater effectiveness than the standard treatment losartan.

PHYTOMEDICINE (2021)

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Article Endocrinology & Metabolism

Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs

Marko Rudar et al.

Summary: The study demonstrates that premature birth blunts both insulin and amino acid-induced activation of mTORC1-dependent translation initiation and protein synthesis in skeletal muscle, thereby limiting the anabolic response to feeding. This anabolic resistance likely contributes to the reduced accretion of lean mass and extrauterine growth restriction in premature infants.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

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Review Nutrition & Dietetics

Uremic Sarcopenia and Its Possible Nutritional Approach

Annalisa Noce et al.

Summary: Uremic sarcopenia, prevalent in CKD patients, can be ameliorated by nutritional therapy and personalized physical activity program.

NUTRIENTS (2021)

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Review Physiology

Links Between Testosterone, Oestrogen, and the Growth Hormone/Insulin-Like Growth Factor Axis and Resistance Exercise Muscle Adaptations

Nima Gharahdaghi et al.

Summary: Maintenance of skeletal muscle mass throughout life is crucial for health, with physical activity playing a key role due to its impact on hormones like testosterone, estrogen, growth hormone (GH), and insulin-like growth factor (IGF). The interaction of these hormones with processes controlling muscle mass remains unclear, but their importance in muscle adaptation to exercise is highlighted in this review.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Medicine, Research & Experimental

Association between gut dysbiosis and chronic kidney disease: a narrative review of the literature

Zhe Feng et al.

Summary: Chronic kidney disease (CKD) is a serious non-communicable disease that poses a significant burden on healthcare and society. Gut dysbiosis, describing an abnormal intestinal ecology, is closely associated with CKD. They have a bidirectional relationship, with gut dysbiosis increasing CKD risk and complications, while CKD itself can lead to changes in gut microecology. Further studies are needed to elaborate the association between gut dysbiosis and CKD, and explore more treatment options to prevent CKD in patients with gut dysbiosis.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Role of autophagy in muscle disease

Anais Franco-Romero et al.

Summary: Loss of muscle mass and quality in various catabolic conditions can lead to increased morbidity, mortality, and decreased quality of life. Dysregulation of the autophagy-lysosome system is a key mechanism in muscle wasting. This review focuses on the role of this system in muscle loss and the signaling pathways involved in its regulation.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Review Pharmacology & Pharmacy

Skeletal muscle atrophy: From mechanisms to treatments

Lin Yin et al.

Summary: Skeletal muscle is crucial for various bodily functions, but pathological issues can lead to muscle wasting and atrophy, characterized by weakness and reduced mass. While exercise is effective, it is not universally applicable, highlighting the need for further research into treatment options.

PHARMACOLOGICAL RESEARCH (2021)

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Article Nutrition & Dietetics

Oyster Hydrolysates Attenuate Muscle Atrophy via Regulating Protein Turnover and Mitochondria Biogenesis in C2C12 Cell and Immobilized Mice

So-Hyun Jeon et al.

Summary: The study found that oyster hydrolysates TGPN and PNY can inhibit sarcopenia by regulating protein turnover and mitochondrial biogenesis, thus improving muscle strength and mass.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Relationship between chronic kidney disease and sarcopenia

Ming-Dian Yu et al.

Summary: The study found that the prevalence of sarcopenia is significantly higher in patients with chronic kidney disease (CKD), and the degree of muscle loss is closely related to the progression of CKD.

SCIENTIFIC REPORTS (2021)

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Article Food Science & Technology

Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway

Takehiro Nakano et al.

Summary: Indoxyl sulfate (IS) activates mTORC1, promoting renal fibrosis; IS also induces epithelial-mesenchymal transition and inflammatory response, which are associated with renal fibrosis; Therapeutic interventions targeting IS and mTORC1 could be effective against renal fibrosis in CKD.

TOXINS (2021)

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Review Geriatrics & Gerontology

Effects of hormonal changes on sarcopenia in chronic kidney disease: where are we now and what can we do?

Ozkan Gungor et al.

Summary: Sarcopenia, a condition characterized by accelerated loss of muscle mass and function, is a major focus of research due to its impact on health-related quality of life and mortality. Hormonal imbalances, such as low testosterone levels and vitamin D deficiency, are common findings in patients with CKD and may contribute to the development of sarcopenia.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Geriatrics & Gerontology

Advanced oxidation protein products contribute to chronic kidney disease-induced muscle atrophy by inducing oxidative stress via CD36/NADPH oxidase pathway

Hiromasa Kato et al.

Summary: This study found that haemodialysis patients with sarcopenia had higher serum AOPPs levels compared to those without sarcopenia, and these levels were negatively correlated with muscle strength. AOPPs contribute to CKD-induced sarcopenia and could be a potential therapeutic target for treatment. Serum AOPPs levels may serve as a new diagnostic marker for sarcopenia in CKD patients.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Pharmacology & Pharmacy

Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway

Wei-Yu Fang et al.

Summary: The study demonstrated that triptolide, obtained from Tripterygium wilfordii Hook F, can prevent inflammation-induced skeletal muscle atrophy by regulating various signaling pathways and molecular mechanisms. The findings suggest potential for triptolide as a novel agent for preventing muscle wasting.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Advances in the Progression and Prognosis Biomarkers of Chronic Kidney Disease

Zhonghong Yan et al.

Summary: Chronic kidney disease (CKD) poses a serious public health concern globally, with issues including inaccurate diagnosis, dependency on biopsies, and multifactorial prognosis challenges in clinical treatment and management. Developing effective biomarkers is crucial for improving CKD prognosis and clinical management.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Physiology

Mechanisms Linking the Gut-Muscle Axis With Muscle Protein Metabolism and Anabolic Resistance: Implications for Older Adults at Risk of Sarcopenia

Konstantinos Prokopidis et al.

Summary: Aging is often associated with sarcopenia, which is characterized by a decline in skeletal muscle mass and function due to muscle anabolic resistance. Recent studies have highlighted the gut-muscle axis as a potential target for combating anabolic resistance and reducing the risk of sarcopenia. Lifestyle approaches that focus on increasing dietary fiber intake, supplementing with prebiotics/probiotics, and combining with exercise training may help in producing short-chain fatty acids (SCFA), increasing microbial diversity, and targeting the gut-muscle axis to mitigate anabolic resistance in older adults.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Urology & Nephrology

New insights into muscle function in chronic kidney disease and metabolic acidosis

Megan Chalupsky et al.

Summary: Sarcopenia, defined as decreased muscle mass or function, is prevalent in chronic kidney disease (CKD) and is associated with decreased physical endurance. Kidney function, inflammation, and oxidative stress are major determinants of muscle mitochondrial function in CKD, with metabolic acidosis (MA) playing a key role in impairing muscle mitochondrial function. Metabolism studies have shown defects in pathways related to mitochondrial energy metabolism and acid-base homeostasis in CKD, leading to insulin resistance. Further research is needed to explore if targeting MA can improve muscle mitochondrial function and insulin resistance, ultimately enhancing physical endurance in CKD patients.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2021)

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Review Biochemistry & Molecular Biology

The Causes and Potential Injurious Effects of Elevated Serum Leptin Levels in Chronic Kidney Disease Patients

Justyna Korczynska et al.

Summary: The high levels of leptin in CKD patients may be due to reduced elimination and increased production of leptin, which could further degrade kidney function and increase cardiovascular risk.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

Celia Andres Juan et al.

Summary: Living species are constantly exposed to oxidants, leading to oxidative stress and disease. The induction of oxidative stress is caused by an imbalance between radical species and antioxidant defense systems, which can damage cellular biomolecules.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nutrition & Dietetics

Maintenance of Skeletal Muscle to Counteract Sarcopenia in Patients with Advanced Chronic Kidney Disease and Especially Those Undergoing Hemodialysis

Katsuhito Mori

Summary: Life extension in modern society has brought new concepts about disorders like frailty and sarcopenia, while advanced technology methods have made it possible to protect patients from lethal chronic kidney disease. Frailty, sarcopenia, and protein energy wasting share common components, with skeletal muscle playing a central role in their etiologies. Recent research suggests that exercise combined with nutritional supplementation may be an effective approach to combat muscle wasting in elderly patients undergoing HD treatments.

NUTRIENTS (2021)

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Article Environmental Sciences

Insulin Withdrawal in Diabetic Kidney Disease: What Are We Waiting for?

Carlos Morillas et al.

Summary: The prevalence of type 2 diabetes mellitus is nearly 9.3%, with 20-40% of patients developing diabetic kidney disease (DKD). Overweight or obese patients often have insulin resistance, but GLP1-RA and SGLT2i have shown benefits for renal and cardiovascular targets in CKD patients. New guidelines recommend the use of these medications in the treatment of CKD patients.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Geriatrics & Gerontology

Association of sarcopenia with mortality and end-stage renal disease in those with chronic kidney disease: a UK Biobank study

Thomas J. Wilkinson et al.

Summary: This study investigated the prevalence of sarcopenia in individuals with chronic kidney disease (CKD) and its association with all-cause mortality and progression to end-stage renal disease (ESRD). The results showed that the presence of sarcopenia in CKD patients was associated with older age, inflammation, poorer renal function, and lower levels of serum albumin, total testosterone, and hemoglobin. The study also found that individuals with CKD and sarcopenia had a higher risk of mortality and progression to ESRD compared to those without sarcopenia, highlighting the importance of early identification and interventions for sarcopenia in at-risk individuals.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Biochemistry & Molecular Biology

Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis

Emma L. Watson et al.

Summary: The study found that vitamin D deficiency is not a prominent factor driving the loss of muscle mass in CKD patients, but may play a role in reduced exercise capacity.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Neurosciences

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Wenjing Ma et al.

Summary: The study reveals the potential role of HDAC4 in denervation-induced muscle atrophy, with its inhibition showing promise in alleviating muscle loss and enhancing the expression of key proteins associated with muscle health. This suggests that HDAC4 inhibitors may serve as a potential treatment for neurogenic muscle atrophy.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

Wai W. Cheung et al.

Summary: By studying the effects of cytokines on cachexia in chronic kidney disease, it was found that IL-1 receptor antagonism may represent a novel targeted treatment for adipose tissue browning and muscle wasting in CKD.

SCIENTIFIC REPORTS (2021)

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Article Geriatrics & Gerontology

Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients

Laurence Genton et al.

Summary: This multicentre study evaluated the effects of glycine and BCAAs on gut barrier and microbiota in haemodialysis patients. The results showed no impact on serum levels of cytokines, appetite mediators, intestinal permeability, endocannabinoids, or faecal IgA. Overall, faecal microbiota composition and diversity did not change with glycine or BCAA supplementation, but there was a decrease in the abundance of L. paracasei and B. dentium.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Review Urology & Nephrology

Cardiovascular Disease Risk Factors in Chronic Kidney Disease in Children

Mark M. Mitsnefes

Summary: Over the past 20 years, cardiovascular disease has been recognized as an important complication of chronic kidney disease (CKD) and a leading cause of death in children and young adults with CKD. Early cardiovascular abnormalities progress during the course of CKD in children. The study aims to characterize the prevalence and evolution of cardiovascular disease risk factors in progressive CKD.

SEMINARS IN NEPHROLOGY (2021)

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Article Urology & Nephrology

Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency

Andrew S. Levey et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Review Transplantation

Skeletal muscle wasting in chronic kidney disease: the emerging role of microRNAs

Kate A. Robinson et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Review Urology & Nephrology

Potassium binding for conservative and preservative management of chronic kidney disease

Deborah J. Clegg et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2020)

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Review Endocrinology & Metabolism

Muscle-Organ Crosstalk: The Emerging Roles of Myokines

Mai Charlotte Krogh Severinsen et al.

ENDOCRINE REVIEWS (2020)

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Review Genetics & Heredity

The Role of Wnt Signalling in Chronic Kidney Disease (CKD)

Soniya A. Malik et al.

GENES (2020)

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Article Endocrinology & Metabolism

Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus

Laure Delavallee et al.

MOLECULAR METABOLISM (2020)

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Review Urology & Nephrology

Targeting the progression of chronic kidney disease

Marta Ruiz-Ortega et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Review Urology & Nephrology

Advances in exercise therapy in predialysis chronic kidney disease, hemodialysis, peritoneal dialysis, and kidney transplantation

Thomas J. Wilkinson et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2020)

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Article Physiology

Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation

Yuntian Shen et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Urology & Nephrology

Veverimer: An Emerging Potential Treatment Option for Managing the Metabolic Acidosis of CKD

Horacio J. Adrogue et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

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Article Transplantation

Contribution of uremic dysbiosis to insulin resistance and sarcopenia

Kiyotaka Uchiyama et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Review Biochemistry & Molecular Biology

Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease

Abdullah Al Mamun et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2020)

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Article Biochemistry & Molecular Biology

NOX1 Inhibition Attenuates Kidney Ischemia-Reperfusion Injury via Inhibition of ROS-Mediated ERK Signaling

Hee-Yeon Jung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway

Rong Hu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Multidisciplinary Sciences

Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers

Heloisa Westphalen et al.

SCIENTIFIC REPORTS (2020)

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Review Cell Biology

Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy

Tadashi Yoshida et al.

CELLS (2020)

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Review Food Science & Technology

Effects of Chronic Kidney Disease and Uremic Toxins on Extracellular Vesicle Biology

Linda Yaker et al.

TOXINS (2020)

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Article Oncology

RNA sequencing (RNA-seq) analysis of gene expression provides new insights into hindlimb unloading-induced skeletal muscle atrophy

Qihao Cui et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Oncology

Inhibition of IL-6/JAK/STAT3 pathway rescues denervation- induced skeletal muscle atrophy

Ziwei Huang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Exploring the Preventive Effect and Mechanism of Senile Sarcopenia Based on Gut-Muscle Axis

Xiaoshan Liao et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Chemistry, Medicinal

Ubiquitin-proteasome system (UPS) as a target for anticancer treatment

Jinyoung Park et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

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Article Physiology

Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease

Liping Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

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Article Health Care Sciences & Services

Symptoms and impacts in anemia of chronic kidney disease

Susan D. Mathias et al.

JOURNAL OF PATIENT-REPORTED OUTCOMES (2020)

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Article Nutrition & Dietetics

Amino acid profile after oral nutritional supplementation in hemodialysis patients with protein-energy wasting

Sylwia Malgorzewicz et al.

NUTRITION (2019)

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Review Pediatrics

Oxidative stress in chronic kidney disease

Kristien Daenen et al.

PEDIATRIC NEPHROLOGY (2019)

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Review Biochemistry & Molecular Biology

Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects

Hayden Hyatt et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2019)

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Article Geriatrics & Gerontology

LncIRS1 controls muscle atrophy via sponging miR-15 family to activate IGF1-PI3K/AKT pathway

Zhenhui Li et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

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Article Geriatrics & Gerontology

Muscle wasting in patients with end-stage renal disease or early-stage lung cancer: common mechanisms at work

Julien Aniort et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

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Article Cell Biology

Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears

Rongzong Zheng et al.

CELL AND TISSUE RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades

Chih-Ying Changchien et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

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Review Cell Biology

The role of satellite and other functional cell types in muscle repair and regeneration

Bide Chen et al.

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2019)

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Article Cell Biology

NADPH Oxidase Hyperactivity Contributes to Cardiac Dysfunction and Apoptosis in Rats with Severe Experimental Pancreatitis through ROS-Mediated MAPK Signaling Pathway

Yi Wen et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Urology & Nephrology

Effects of Treatment of Metabolic Acidosis in CKD: A Systematic Review and Meta-Analysis

Sankar D. Navaneethan et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

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Review Medicine, General & Internal

Chronic Kidney Disease Diagnosis and Management: A Review

Teresa K. Chen et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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