Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 3, Pages 649-654Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3379-15.2016
Keywords
cochlea; membrane capacitance; patch-clamp; synaptic release
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Funding
- Agence Nationale pour la Recherche [ANR-13-JSV1-0009-01]
- Fondation pour l'Avenir
- Montpellier University postdoctoral fellowship
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Exocytosis at the inner hair cell ribbon synapse is achieved through the functional coupling between calcium channels and glutamate-filled synaptic vesicles. Using membrane capacitance measurements, we investigated whether the actin network regulates the exocytosis of synaptic vesicles at the mouse auditory hair cell. Our results suggest that actin network disruption increases exocytosis and that actin filaments may spatially organize a subfraction of synaptic vesicles with respect to the calcium channels.
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