Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 650, Issue -, Pages 17-20Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2023.01.028
Keywords
RNA; Translational diffusion coefficient; Rotational diffusion coefficient; Empirical model
Categories
Ask authors/readers for more resources
Diffusion is an inevitable prerequisite for ribonucleic acids to regulate gene expression and perform gene editing. The empirical models derived in this study accurately predict the three-dimensional translational and rotational diffusion velocities of RNA.
Inevitable precondition for ribonucleic acids to regulate gene expression and to perform gene editing is diffusion. Free three-dimensional translational diffusion velocity of RNA of up to 200 nucleotides could be predicted with high accuracy by the empirical model D = 4.58 10-10N-0.39 m2s-1. Furthermore, the biological function of ribonucleic acids is determined by rotational diffusion. In the presented work, an empirical model is derived applying atom-level shell-modeling of electron density maps, Dr = 1.62 109 N-1.20 s-1, to predict the rotational diffusion coefficient of short ribonucleic acids based on the polymer size.(c) 2023 Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available