Different additives of gold nanoparticles and lithium oxide loaded chitosan based films; controlling optical and structural properties, evaluating cell viability

Natural chitosan-based films (CS) were fabricated by changing ingredient corporations between gold nanoparticles (AuNPs), lithium oxide (Li2O), and graphene oxide (GO). A Series of films with different components were obtained. The structural examination is executed by XRD, FTIR, and EDX to analyze crystal structure, chemical bonding, and chemical contents, respectively. The findings illustrated that, the Li2O@CS exhibited the lowest contact angle with 70 +/- 4.6 degrees. Scanning Electron Microscopy (SEM) displayd rod-shaped AuNPs with an average length of 0.3 mm and an average width of 90 nm. The refractive index of CS recorded 2.142, while AuNPs/Li2O/GO@CS slightly declined to 2.085. Concerning AuNPs/Li2O/ GO@CS, the detected cell viability percentage of normal lung cells among the usage of 156.25 mg/mL is 98.91%, while 9.77 mg/mL achieved 125.78%. Therefore, combining AuNPs, GO and Li2O within the CS matrix results in films of boosted biocompatibility and can be suggested for medical applications. (c) 2023 Elsevier Inc. All rights reserved.

Automated summary

Natural chitosan-based films (CS) were prepared by changing the ingredient combinations of gold nanoparticles (AuNPs), lithium oxide (Li2O), and graphene oxide (GO). The structural properties of the films were examined using XRD, FTIR, and EDX techniques. The results showed that Li2O@CS had the lowest contact angle of 70 +/- 4.6 degrees. SEM analysis revealed that the AuNPs were rod-shaped with an average length of 0.3 mm and an average width of 90 nm. The refractive index of CS was 2.142, which slightly decreased to 2.085 for AuNPs/Li2O/GO@CS. In terms of cell viability, AuNPs/Li2O/GO@CS showed a viability percentage of 98.91% for normal lung cells at a concentration of 156.25 mg/mL, while 9.77 mg/mL achieved 125.78%. Therefore, the combination of AuNPs, GO, and Li2O in the CS matrix enhances biocompatibility and has potential applications in medicine. (c) 2023 Elsevier Inc. All rights reserved.