Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression

We have previously shown that monoamine oxidase A (MAO A) mediates prostate cancer growth and metastasis. Further, MAO A/Pten double knockout (DKO) mice were generated and demonstrated that the deletion of MAO A delayed prostate tumor development in the Pten knockout mouse model of prostate adenocarcinoma. Here, we investigated its effect on immune cells in the tumor microenvironment in MAO A/Pten DKO mouse model. Our results shows that Paraffin embedded prostate tissues from MAO A/ Pten DKO mice had elevated markers of immune stimulation (CD8 thorn cytotoxic T cells, granzyme B, and IFNg) and decreased expression of markers of immune suppression (FoxP3, CD11b, HIF-1-alpha, and arginase 1) compared to parental Pten knockouts (MAO A wildtype). CD11b thorn myeloid derived suppressor cells (MDSC) were the primary immunosuppressive cell types in these tumors. The data suggest that deletion of MAO A reduces immune suppression in prostate tumors to enhance antitumor immunity in prostate cancer. Thus, MAO A inhibitor may alleviate immune suppression, increase the antitumor im-mune response and be used for cancer immunotherapy. (c) 2022 Elsevier Inc. All rights reserved.

Automated summary

This study investigates the effect of MAO A deletion on immune cells in the tumor microenvironment using a MAO A/Pten DKO mouse model. The results show that the deletion of MAO A reduces immune suppression in prostate tumors and enhances antitumor immunity, suggesting that MAO A inhibitors may have potential for cancer immunotherapy.