Related references
Note: Only part of the references are listed.AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin
Matteo Rossi Sebastiano et al.
DRUG DISCOVERY TODAY (2022)
Prediction of Protein-Protein Interactions Between Alsin DH/PH and Rac1 and Resulting Protein Dynamics
Marco Cannariato et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)
ALS2 regulates endosomal trafficking, postsynaptic development, and neuronal survival
Joohyung Kim et al.
JOURNAL OF CELL BIOLOGY (2021)
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2
Kento Shimakura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)
ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes
Suzuka Ono et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria
FoSheng Hsu et al.
ELIFE (2018)
Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function
Kai Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms
Mukesh Gautam et al.
HUMAN MOLECULAR GENETICS (2016)
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
Asako Otomo et al.
FEBS LETTERS (2011)
Alsin and SOD1G93A Proteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity
Qiang Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice
Shinji Hadano et al.
NEUROSCIENCE RESEARCH (2010)
Loss of ALS2/Alsin Exacerbates Motor wDysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
Shinji Hadano et al.
PLOS ONE (2010)
ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth
Asako Otomo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Molecular interaction of neurocalcin α with alsin (ALS2)
Toshinori Masutani et al.
NEUROSCIENCE LETTERS (2008)
The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis
Ryota Kunita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics
Kyoko Suzuki-Utsunomiya et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
S Hadano et al.
HUMAN MOLECULAR GENETICS (2006)
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth
EL Tudor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking
R Kunita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease
K Yamanaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
A Otomo et al.
HUMAN MOLECULAR GENETICS (2003)
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
Y Yang et al.
NATURE GENETICS (2001)
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
S Hadano et al.
NATURE GENETICS (2001)