Delay discounting in Parkinson?s disease: A systematic review and meta-analysis

Delay discounting refers to the depreciation of the value of a reward as a function of the time it takes to obtain it. Growing evidence shows altered delay discounting in several pathological conditions, including neurological disorders. Here, we conducted a systematic review and meta-analysis of the published literature on delay dis-counting (DD) in Parkinson's Disease (PD). We found steeper DD in patients with PD, compared to healthy controls, both in on and off dopaminergic medication. These results confirm altered DD in PD and suggest an independent influence of the dopaminergic medication and the clinical condition itself on it. Also the effect of impulse control disorder and of pharmacological treatments are analysed.

Automated summary

This study conducted a systematic review and meta-analysis on delay discounting (DD) in Parkinson's Disease (PD), and found that patients with PD have steeper delay discounting compared to healthy controls, both on and off dopaminergic medication. These results confirm the altered delay discounting in PD and suggest the independent influence of dopaminergic medication and the clinical condition itself.