Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 12, Pages 3441-3452Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2577-15.2016
Keywords
motor systems; nanotechnology; phrenic nucleus; plasticity; respiratory recovery; spinal cord injury
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Funding
- National Institute of Health [HD-31550]
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Respiratory complications in patients with spinal cord injury (SCI) are common and have a negative impact on the quality of patients' lives. Systemic administration of drugs that improve respiratory function often cause deleterious side effects. The present study examines the applicability of a novel nanotechnology-based drug delivery system, which induces recovery of diaphragm function after SCI in the adult rat model. We developed a protein-coupled nanoconjugate to selectively deliver by transsynaptic transport small therapeutic amounts of an A1 adenosine receptor antagonist to the respiratory centers. A single administration of the nanoconjugate restored 75% of the respiratory drive at 0.1% of the systemic therapeutic drug dose. The reduction of the systemic dose may obviate the side effects. The recovery lasted for 4 weeks (the longest period studied). These findings have translational implications for patients with respiratory dysfunction after SCI.
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