Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 13, Pages 3660-3675Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4368-15.2016
Keywords
hippocampus; lateral entorhinal cortex; medial entorhinal cortex; memory; perirhinal cortex
Categories
Funding
- National Institute of Mental Health [MH-94263, MH051570]
- ONR MURI [N00014-10-1-0936]
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It is commonly conceived that the cortical areas of the hippocampal region are functionally divided into the perirhinal cortex (PRC) and the lateral entorhinal cortex (LEC), which selectively process object information; and the medial entorhinal cortex (MEC), which selectively processes spatial information. Contrary to this notion, in rats performing a task that demands both object and spatial information processing, single neurons in PRC, LEC, and MEC, including those in both superficial and deep cortical areas and in grid, border, and head direction cells of MEC, have a highly similar range of selectivity to object and spatial dimensions of the task. By contrast, representational similarity analysis of population activity reveals a key distinction in the organization of information in these areas, such that PRC and LEC populations prioritize object over location information, whereas MEC populations prioritize location over object information. These findings bring to the hippocampal system a growing emphasis on population analyses as a powerful tool for characterizing neural representations supporting cognition and memory.
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