Journal
JOURNAL OF NEUROSCIENCE
Volume 36, Issue 15, Pages 4231-4247Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3648-15.2016
Keywords
cortex; hippocampus; learning and memory; memory consolidation; sleep slow oscillations; thalamus
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Funding
- Office of Naval Research/Multidisciplinary University Research Initiative [N000141310672]
- National Institutes of Health [R01 EB009282, R01 MH099645]
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Sleep is critical for regulation of synaptic efficacy, memories, and learning. However, the underlying mechanisms of how sleep rhythms contribute to consolidating memories acquired during wakefulness remain unclear. Here we studied the role of slow oscillations, 0.2-1 Hz rhythmic transitions between Up and Down states during stage 3/4 sleep, on dynamics of synaptic connectivity in the thalamocortical network model implementing spike-timing-dependent synaptic plasticity. We found that the spatiotemporal pattern of Up-state propagation determines the changes of synaptic strengths between neurons. Furthermore, an external input, mimicking hippocampal ripples, delivered to the cortical network results in input-specific changes of synaptic weights, which persisted after stimulation was removed. These synaptic changes promoted replay of specific firing sequences of the cortical neurons. Our study proposes a neuronal mechanism on how an interaction between hippocampal input, such as mediated by sharp wave-ripple events, cortical slow oscillations, and synaptic plasticity, may lead to consolidation of memories through preferential replay of cortical cell spike sequences during slow-wave sleep.
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