Temporal lipid profiling in the progression from acute to chronic heart failure in mice and ischemic human hearts

Article Agriculture, Multidisciplinary

Lipid fingerprinting of yellow mealworm Tenebrio molitor by untargeted liquid chromatography-mass spectrometry

S. G. B. Gowda et al.

Summary: Yellow mealworm larvae (T. molitor) are insects rich in proteins and various functional lipids, which have great nutritional and health value. They could be developed into functional food and feed products.

JOURNAL OF INSECTS AS FOOD AND FEED (2022)

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Article Cardiac & Cardiovascular Systems

Lipid Profiles and Heart Failure Risk Results From Two Prospective Studies

Clemens Wittenbecher et al.

Summary: This study identified and validated two lipid metabolites and several lipidomics patterns as potential novel biomarkers of HF risk. Lipid profiling may capture preclinical molecular alterations that predispose to incident HF.

CIRCULATION RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Heart failure after myocardial infarction: incidence and predictors

Dominik Jenca et al.

Summary: Heart failure remains a common complication of myocardial infarction. Timely identification of at-risk individuals and early initiation of guideline-directed therapy can reduce the burden of heart failure.

ESC HEART FAILURE (2021)

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Article Physiology

Lipidomics Revealed Alteration of Sphingolipid Metabolism During the Reparative Phase After Myocardial Infarction Injury

Tong Hua et al.

Summary: Studies using a mouse model revealed alterations in cardiac sphingolipid metabolism during the reparative phase post-myocardial infarction (MI), with ceramide-1-phosphates accumulating significantly. Changes in myocardial sphingolipids were more pronounced compared to plasma sphingolipids after MI injury. Upregulation of ceramide kinase, which generates ceramide-1-phosphates, was observed in heart tissue post-MI, indicating its potential role in ischemic heart disease.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Multidisciplinary Sciences

Depletion of cardiac cardiolipin synthase alters and diastolic function

Elia Smeir et al.

Summary: The study found that cardiolipin synthase (CLS) affects cardiac function and plays an important role in regulating cardiac function, while CL72:8 is significantly decreased in cardiac samples from heart failure patients. Therefore, targeting CLS may be an effective approach for treating heart failure.

ISCIENCE (2021)

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Article Cardiac & Cardiovascular Systems

Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts

SiddabasaveGowda B. Gowda et al.

Summary: The study explored the relationship between S1P and heart failure, revealing the association between S1P and cardiac repair, as well as the importance of S1P/S1PR1 signaling in cardiac repair in mice. S1P may serve as a therapeutic target for clinical cardiac protection.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

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Review Multidisciplinary Sciences

Obesity treatment: Weight loss versus increasing fitness and physical activity for reducing health risks

Glenn A. Gaesser et al.

Summary: Aerobic fitness and physical activity play a crucial role in improving cardiometabolic risk markers and reducing mortality risk, more effectively than weight-loss programs. Weight loss does not necessarily reduce mortality risk, while intentional increases in physical activity can bring more benefits.

ISCIENCE (2021)

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Article Cardiac & Cardiovascular Systems