☆ 4.4 Article

Efficacy and mechanism of the antinociceptive effects of cannabidiol on acute orofacial nociception induced by Complete Freund's Adjuvant in male Mus musculus mice

ARCHIVES OF ORAL BIOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Anesthesiology

The glial cell's role in antinociceptive differential effects of oxytocin upon female and male rats

Ana B. Salinas-Abarca et al.

Summary: Sexual dimorphism plays a significant role in pain processing and response to analgesic drugs. Oxytocin showed a preference for preventing LPS-induced hypersensitivity in male rats compared to females, indicating a potential gender-specific analgesic effect. The results suggest that different strategies may be needed to treat pain in men and women, with oxytocin potentially being more effective for pain with an inflammatory component in men.

EUROPEAN JOURNAL OF PAIN (2022)

Add to Collection

Article Plant Sciences

Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice

Ananya Buapratoom et al.

Summary: ECa 233 showed anti-nociceptive effects on chronic neuropathic orofacial pain in mice by modulating peripheral calcitonin gen-related peptide expression, which decreased nociceptive activity in trigeminal nucleus caudalis. This study also found a synergistic effect of ECa 233 with gabapentin, reducing mechanical hyperalgesia and allodynia in mice. Further clinical trials are needed to explore the efficacy of ECa 233 in treating neuropathic pain in humans.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Sex-dependent pronociceptive role of spinal α5-GABAA receptor and its epigenetic regulation in neuropathic rodents

Urzula Franco-Enzastiga et al.

Summary: This study examined the sexual dimorphism in neuropathic rodents regarding alpha(5)-GABA(A) receptors, revealing an increase in receptor expression in DRG of nerve-injured females and a decrease in males. Ovariectomy abolished the antiallodynic effect of L-655,708 in females, which was restored by estradiol supplementation. In males, DNA methylation inhibition increased the receptor expression and enabled the antinociceptive effect, suggesting a potential treatment target for chronic pain in females.

JOURNAL OF NEUROCHEMISTRY (2021)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

CGRP Modulates Orofacial Pain through Mediating Neuron-Glia Crosstalk

H. Liang et al.

Summary: CGRP is upregulated in trigeminal neurons and SGCs following orofacial pain induction. Knockdown of CGRP reduces pain and its expression in neurons and SGCs. CGRP upregulates inducible nitric oxide synthase in SGCs through p38 signaling pathway, leading to a positive-feedback neuron-glia crosstalk mediated by CGRP.

JOURNAL OF DENTAL RESEARCH (2021)

Add to Collection

Review Neurosciences

Cannabidiol: pharmacology and therapeutic targets

Stevie C. Britch et al.

Summary: CBD products are commonly used for self-treatment without regulatory approval, with limited scientific evidence from clinical trials. Epidiolex is the only rigorously evaluated product approved for intractable childhood-onset seizures, while studies on CBD for other medical conditions are limited in number and often lack scientific rigor.

PSYCHOPHARMACOLOGY (2021)

Add to Collection

Article Neurosciences

Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors

Anamaria Falcao Pereira et al.

Summary: This study found that modulation of the endocannabinoid system through the CB1 receptor can alleviate oxaliplatin-induced peripheral sensory neuropathy. Cannabidiol and WIN 55,212-2 can improve mechanical hyperalgesia and c-Fos expression in the spinal cord, while a CB1 antagonist can accelerate cold allodynia response and a CB2 antagonist fails to modulate oxaliplatin-induced nociceptive behavior.

NEUROTOXICITY RESEARCH (2021)

Add to Collection

Review Neurosciences

Review of Literatures: Physiology of Orofacial Pain in Dentistry

Nattapon Rotpenpian et al.

Summary: This article provides a summary of the physiology of orofacial pain in dentistry, focusing on the pain pathway, molecular mechanisms of pain pathophysiology, and new insights into classification of orofacial pain related diseases. It also delves into the possible mechanisms of neuropathic orofacial pain, distinguishing it from other types of pain.

ENEURO (2021)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Nociceptive receptors are expressed differently in trigeminal nociception after lingual nerve injury and unilateral external carotid artery occlusion in rats

Aree Wanasuntronwong et al.

Summary: The study investigated the changes in nociceptive activity in two animal models of trigeminal neuropathic pain in rats, finding that both unilateral external carotid artery ischemic reperfusion and lingual nerve crush increased nociceptive activity at the trigeminal nucleus caudalis. However, the fEPSPs and expression of nociceptive peripheral afferent neurons differed between the two models.

ARCHIVES OF ORAL BIOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Acute and Chronic Pain from Facial Skin and Oral Mucosa: Unique Neurobiology and Challenging Treatment

Man-Kyo Chung et al.

Summary: The oral cavity is a portal into the digestive system with unique sensory properties. The oral mucosa needs to be sensitive and selective to differentiate harmful toxins from edible food, but also insensitive to endure noxious irritation. Chronic pain in the oral mucosa is often due to ulcers, and conditions like atypical odontalgia and burning mouth syndrome pose challenges in diagnosis and treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Evolution of mirror-image pain in temporomandibular joint osteoarthritis mouse model

Nattapon Rotpenpian et al.

Summary: By studying mirror-image pain in an osteoarthritis mouse model of the temporomandibular joint, it was found that nocifensive behaviors on the contralateral side became stronger on day 28, in correlation with elevated phosphorylated cyclic AMP response element binding protein and microglia marker in the trigeminal subnucleus caudalis, indicating the occurrence of mirror-image pain.

JOURNAL OF APPLIED ORAL SCIENCE (2021)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

A standardized extract of Centella asiatica (ECa 233) prevents temporomandibular joint osteoarthritis by modulating the expression of local inflammatory mediators in mice

Nattapon Rotpenpian et al.

Summary: The study showed that the expression of TRPV1, ASIC3, and CGRP significantly increased in mice with TMJ-OA on day 21 after injecting complete Freund's adjuvant. However, ECa 233 was more effective than ibuprofen in reducing the expression of TRPV1 and ASIC3, thereby inhibiting the pathogenesis of temporomandibular joint osteoarthritis.

JOURNAL OF APPLIED ORAL SCIENCE (2021)

Add to Collection

Article Pharmacology & Pharmacy

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions

Xia Li et al.

CLINICAL PHARMACOKINETICS (2020)

Add to Collection

Review Urology & Nephrology

NSAIDs in CKD: Are They Safe?

Megan Baker et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

Add to Collection

Article Clinical Neurology

CBD Effects on TRPVI Signaling Pathways in Cultured DRG Neurons

Uma Anand et al.

JOURNAL OF PAIN RESEARCH (2020)

Add to Collection

Article Neurosciences

CB1-cannabinoid-, TRPV1-vanilloid- and NMDA-glutamatergic-receptor-signalling systems interact in the prelimbic cerebral cortex to control neuropathic pain symptoms

Priscila Medeiros et al.

BRAIN RESEARCH BULLETIN (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action

Jakub Mlost et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Pharmacology & Pharmacy

Diversity of molecular targets and signaling pathways for CBD

Douglas L. de Almeida et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2020)

Add to Collection

Article Neurosciences

Peripheral and central substance P expression in rat CFA-induced TMJ synovitis pain

Liqin Xu et al.

MOLECULAR PAIN (2019)

Add to Collection

Article Chemistry, Medicinal

Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

Mojgan Aghazadeh Tabrizi et al.

MEDICINAL RESEARCH REVIEWS (2017)

Add to Collection

Article Clinical Neurology

Inhibition of Reinforcing, Hyperalgesic, and Motor Effects of Morphine by Buspirone in Rats

Darakhshan Jabeen Haleem et al.

JOURNAL OF PAIN (2017)

Add to Collection

Article Anesthesiology

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

Holly T. Philpott et al.

PAIN (2017)

Add to Collection

Article Anesthesiology

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis

D. C. Hammell et al.

EUROPEAN JOURNAL OF PAIN (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Whirlin increases TRPV1 channel expression and cellular stability

Maria Grazia Ciardo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Add to Collection

Review Pharmacology & Pharmacy

Development of anti-migraine therapeutics using the capsaicin-induced dermal blood flow model

Linde Buntinx et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Add to Collection

Review Clinical Neurology

Reported concepts for the treatment modalities and pain management of temporomandibular disorders

Mieszko Wieckiewicz et al.

JOURNAL OF HEADACHE AND PAIN (2015)

Add to Collection

Editorial Material Health Care Sciences & Services

Editorial, supportive care and psychological issues around cancer

Elie Isenberg-Grzeda et al.

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2015)

Add to Collection

Review Physiology

CALCITONIN GENE-RELATED PEPTIDE: PHYSIOLOGY AND PATHOPHYSIOLOGY

F. A. Russell et al.

PHYSIOLOGICAL REVIEWS (2014)

Add to Collection

Review Health Care Sciences & Services

Descending pain modulation and chronification of pain

Michael H. Ossipov et al.

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2014)

Add to Collection

Article Clinical Neurology

Spontaneous Behavioral Responses in the Orofacial Region: A Model of Trigeminal Pain in Mouse

Marcela Romero-Reyes et al.

HEADACHE (2013)

Add to Collection

Article Neurosciences

Quantifying altered long-term potentiation in the CA1 hippocampus

T. Saleewong et al.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2012)

Add to Collection

Article Physiology

Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons

Olga Kopach et al.

FRONTIERS IN PHYSIOLOGY (2012)

Add to Collection

Article Cell Biology

Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension

Dachun Yang et al.

CELL METABOLISM (2010)

Add to Collection

Article Cardiac & Cardiovascular Systems

Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome

Ian N. Bratz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Add to Collection

Article Anesthesiology

Capsaicin Combined with Local Anesthetics Preferentially Prolongs Sensory/Nociceptive Block in Rat Sciatic Nerve

Peter Gerner et al.

ANESTHESIOLOGY (2008)

Add to Collection

Article Neurosciences

TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons

Ning Qin et al.

JOURNAL OF NEUROSCIENCE (2008)

Add to Collection

Article Clinical Neurology

Neuropathic pain symptoms relative to overall pain rating

MM Backonja et al.

JOURNAL OF PAIN (2004)

Add to Collection

Article Pharmacology & Pharmacy

Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons

TJ Price et al.

BRITISH JOURNAL OF PHARMACOLOGY (2004)

Add to Collection

Review Pharmacology & Pharmacy

Profound, non-opioid analgesia produced by the high-efficacy 5-HT1A agonist F 13640 in the formalin model of tonic nociceptive pain

L Bardin et al.

PHARMACOLOGY (2003)

Add to Collection

Article Pharmacology & Pharmacy

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

T Bisogno et al.

BRITISH JOURNAL OF PHARMACOLOGY (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.