Journal
ARCHIVES OF MEDICAL SCIENCE
Volume 19, Issue 1, Pages 237-241Publisher
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/aoms/156490
Keywords
obstructive sleep apnea-hypopnea syndrome; hypertension; continuous positive airway pressure; mechanism
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This study aimed to investigate the effects of continuous positive airway pressure (CPAP) on hypertension in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to understand the underlying mechanisms. The results showed that CPAP significantly improved clinic, ambulatory, and home blood pressure, and this improvement was correlated with a decrease in biomarkers of inflammation and oxidative stress. In conclusion, CPAP has a significant antihypertensive effect on OSAHS patients, especially nocturnal hypertension, possibly by counteracting inflammation and oxidative stress.
Introduction: The work was designed to investigate the effect of continuous positive airway pressure (CPAP) on hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and to elucidate the underlying mechanisms. Methods: We examined the effect of CPAP on blood pressure and biomarkers reflecting inflammation and oxidative stress, and investigated the correlation between changes in blood pressure and the biomarkers. Results: CPAP significantly improved clinic, ambulatory and home blood pressure (p < 0.05). The hypotensive effect of CPAP was positively correlated with the decrease of interleukin-6, C-reactive protein, NADPH oxidase and malonaldehyde. Conclusions: CPAP has a significant antihypertensive effect on OSAHS patients, especially nocturnal hypertension, possibly by counteracting inflammation and oxidative stress.
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