Journal
APPLIED SURFACE SCIENCE
Volume 606, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2022.154779
Keywords
Soft X-ray; extreme ultraviolet (SXR; EUV) radiation; Low-temperature plasma treatment; Electrospun polycaprolactone (PCL) nonwovens; XPS analysis; L929 mouse fibroblasts; Cytocompatibility enhancement
Categories
Funding
- National Science Centre, Poland [UMO-2019/03/X/ST5/01643]
- Military University of Technology [UGB 731/2022]
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In this study, a novel method of physicochemical modification and bioactivity enhancement of electrospun fibrous polycaprolactone (PCL) nanofibers using soft X-ray/extreme ultraviolet (SXR/EUV) irradiation and low-temperature plasma treatment was reported. The modified PCL nanofibers showed cyto-compatible and non-cytotoxic properties, as well as enhanced cell adhesion and proliferation.
The fundamental aspect of the fabrication of microporous, fibrous biomaterials in form of scaffolds is the optimization of their surface properties to enhance cellular response. In this work, a novel approach to physicochemical modification and bioactivity enhancement of electrospun fibrous polycaprolactone (PCL) nonwovens using soft X-ray/extreme ultraviolet (SXR/EUV) irradiation and exposure to a low-temperature, SXR/EUV induced, nitrogen and oxygen plasmas is presented for the first time. Chemical alterations and morphology of the fibrous structure of irradiated PCL mats were examined using Xray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM), respectively. The impact of introduced changes on viability, morphology, and adhesion of L929 mouse fibroblasts was examined. It was found that simultaneous interaction of SXR/EUV radiation and N2 or O2 photoionized plasmas led to strong chemical decomposition of the surface of fibrous PCL mats. Also, mats' spatial porous structure was not damaged and the fibers were not broken or fused. All modified samples demonstrated cyto-compatible and non-cytotoxic properties. Enhancement of L929 cell adhesion and increased proliferation were also observed.
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