Journal
APPLIED SURFACE SCIENCE
Volume 610, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2022.155610
Keywords
Silver-decorated; Antibacterial; Anticancer; Drug delivery
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Incorporating Ag nanoparticles into core-shell Fe3O4@SiO2 offers promising opportunities for biomedical applications. Fe3O4@SiO2-Ag nanoparticles were successfully synthesized using seed-mediated growth methods. The synthesized composite nanoparticles exhibited good crystallinity and a core-shell structure. The nanocomposites also showed superparamagnetic properties and surface plasmon resonance absorption. Moreover, the Fe3O4@SiO2-Ag nanoparticles demonstrated potential antibacterial activity and cytotoxicity against cancer cells, indicating their potential as antibacterial agents and anticancer drug carriers.
Incorporating Ag nanoparticles at core-shell Fe3O4@SiO2 provides promising opportunities for biomedical applications. Here, Fe3O4@SiO2-Ag nanoparticles have been successfully synthesized using seed-mediated growth methods. Based on the results, the as-prepared composite nanoparticles have good crystallinity and a core-shell structure. It was also revealed that the nanocomposites exhibited a superparamagnetic property with a magnetic saturation value of 36.42 emu/g and surface plasmon resonance (SPR) absorption at 370 nm. Furthermore, the result also demonstrated that the as-prepared Fe3O4@SiO2-Ag showed an potential inhibition activity against Escherichia coli and Staphylococcus aureus with an inhibition zone of about 8-10 mm. In addition, an in-vitro MTS assay also revealed that epirubicin (EPI)-loaded Fe3O4@SiO2-Ag nanoparticles has cytotoxic properties against HeLa cells. This indicates that the as-prepared Fe3O4@SiO2-Ag nanoparticles could potentially be used as both an antibacterial agent and an anticancer drug carrier.
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