Evaluation and bioparticle density correlation analysis of extended gate HEMT sensors for biological detection from microscopic view

In this letter, we focus on the relationship between modification bioparticle density (N) and biological regulation ability in extended gate HEMT (EG-HEMT) biosensors. By analyzing, we demonstrate that under the same gate electrodes size (S (g)) and concentration, N is exponentially related to the area of sensing regions (y) and has fixed exponential magnification -0.65 +/- 0.05. This formula had been demonstrated to have perfect universality when testing protein and small molecules. Finally, we apply N to the structural design of EG-HEMT biosensors and projected that 10 y structure has both high biological regulation ability of biosensors and efficient utility of chips.

Automated summary

In this letter, the relationship between modification bioparticle density (N) and biological regulation ability in extended gate HEMT (EG-HEMT) biosensors is studied. Through analysis, it is demonstrated that N is exponentially related to the area of sensing regions (y) under the same gate electrodes size (S (g)) and concentration, with a fixed exponential magnification of -0.65 +/- 0.05. This formula has been proven to be universally applicable when testing protein and small molecules. Furthermore, the application of N in the structural design of EG-HEMT biosensors suggests that a 10 y structure can provide both high biological regulation ability of biosensors and efficient utilization of chips.