4.7 Article

Deletion of gene OV132 attenuates Orf virus more effectively than gene OV112

Related references

Note: Only part of the references are listed.
Article Oncology

Heterogeneity of HER2 Expression in Circulating Tumor Cells of Patients with Breast Cancer Brain Metastases and Impact on Brain Disease Control

Douglas Guedes de Castro et al.

Summary: The expression of HER2 in circulating tumor cells (CTC) of breast cancer brain metastases (BCBM) patients is associated with longer distant brain failure-free survival, suggesting its potential for treatment selection.

CANCERS (2022)

Article Oncology

Identification of in vitro and in vivo oncolytic effect in colorectal cancer cells by Orf virus strain NA1/11

Daxiang Chen et al.

Summary: This study demonstrated that ORFV strain NA1/11 can effectively inhibit the growth and migration of CRC cells both in vitro and in vivo, and regulates key factors relevant to apoptosis, autoimmunity/inflammation, angiogenesis, and the cell cycle. ORFV infection induces oncolytic activity by enhancing apoptosis, making it a potential therapeutic option for CRC.

ONCOLOGY REPORTS (2021)

Article Immunology

Protective Efficacy of an Orf Virus-Vector Encoding the Hemagglutinin and the Nucleoprotein of Influenza A Virus in Swine

Lok R. Joshi et al.

Summary: The study developed two recombinant orf viruses expressing the HA gene or the HA and NP genes of IAV-S, which induced robust virus neutralizing antibody responses in pigs. The immunization with the HA-NP virus resulted in a Th1-biased immune response and provided incremental protection against challenge infection compared to the HA group.

FRONTIERS IN IMMUNOLOGY (2021)

Article Microbiology

Orf virus ORFV112, ORFV117 and ORFV127 contribute to ORFV IA82 virulence in sheep

Mathias Martins et al.

Summary: Deletion of these IMP genes from the ORFV genome resulted in a slight reduction in virulence in vivo, as evidenced by a reduction in the duration of the clinical disease and virus shedding.

VETERINARY MICROBIOLOGY (2021)

Review Immunology

Innate Lymphocyte Mechanisms in Skin Diseases

Yi-Ling Chen et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Article Veterinary Sciences

Suppression of influenza virus infection by the orf virus isolated in Taiwan

Fong-Yuan Lin et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2015)

Article Virology

Functional Analysis of the Short Isoform of Orf Virus Protein OV20.0

Yeu-Yang Tseng et al.

JOURNAL OF VIROLOGY (2015)

Article Virology

Immune modulation by virus-encoded secreted chemokine binding proteins

Haleh Heidarieh et al.

VIRUS RESEARCH (2015)

Article Microbiology

Genome analysis of orf virus isolates from goats in the Fujian Province of southern China

Xuelin Chi et al.

FRONTIERS IN MICROBIOLOGY (2015)

Article Biochemistry & Molecular Biology

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

Sandeepa M. Eswarappa et al.

Article Biotechnology & Applied Microbiology

ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic

Julia L. Rintoul et al.

MOLECULAR THERAPY (2012)

Article Biochemical Research Methods

Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus) genome

Michael J. McGuire et al.

PROTEOME SCIENCE (2012)

Article Biotechnology & Applied Microbiology

Characterization of immunostimulatory components of orf virus (parapoxvirus ovis)

Astrid Friebe et al.

JOURNAL OF GENERAL VIROLOGY (2011)

Article Biotechnology & Applied Microbiology

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

Maria Hautaniemi et al.

JOURNAL OF GENERAL VIROLOGY (2010)

Article Pharmacology & Pharmacy

Orf: an update on current research and future perspectives

Madhusudan Hosamani et al.

Expert Review of Anti-Infective Therapy (2009)

Article Pharmacology & Pharmacy

The biology of vascular endothelial growth factor-B (VEGF-B)

AD Nash et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2006)

Article Multidisciplinary Sciences

Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors

BT Seet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biotechnology & Applied Microbiology

Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus

O Weber et al.

JOURNAL OF GENERAL VIROLOGY (2003)