Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 75, Issue 2, Pages 175-182Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnen/nlv018
Keywords
Alzheimer disease; Frontotemporal lobar degeneration; Human postmortem brain tissue; Visinin-like 1 protein (Vilip-1)
Categories
Funding
- VAPHS [BX000542]
- [MH16804]
- [AG05133]
- [AG014449]
- [AG027224]
- [P30CA047904]
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Recent studies have implicated the neuronal calcium-sensing protein visinin-like 1 protein (Vilip-1) as a peripheral biomarker in Alzheimer disease (AD), but little is known about expression of Vilip-1 in the brains of patients with AD. We used targeted and quantitative mass spectrometry to measure Vilip-1 peptide levels in the entorhinal cortex (ERC) and the superior frontal gyrus (SF) from cases with early to moderate stage AD, frontotemporal lobar degeneration (FTLD), and cognitively and neuropathologically normal elderly controls. We found that Vilip-1 levels were significantly lower in the ERC, but not in SF, of AD subjects compared to normal controls. In FTLD cases, Vilip-1 levels in the SF were significantly lower than in normal controls. These findings suggest a unique role for cerebrospinal fluid Vilip-1 as a biomarker of ERC neuron loss in AD.
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