Journal
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume 87, Issue 9, Pages 982-992Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2015-311302
Keywords
BENIGN INTRACRAN HYP; CSF DYNAMICS; HEADACHE; NEUROOPHTHALMOLOGY
Categories
Funding
- NIHR Clinician Scientist Fellowship [NIHR-CS-011-028]
- Medical Research Council, UK [MR/K015184/1]
- Medical Research Council [G0601430, MR/K015184/1] Funding Source: researchfish
- National Institute for Health Research [CL-2009-09-001, NIHR-CS-011-028, ACF-2012-09-003] Funding Source: researchfish
- MRC [G0601430, MR/K015184/1] Funding Source: UKRI
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Idiopathic intracranial hypertension (IIH) is a rare but important disease associated with significant morbidity. There is an expected rise in prevalence in line with the escalating global burden of obesity. Modern revisions in the terminology and diagnostic criteria for IIH help guide clinicians in investigations and researchers in standardising recruitment criteria for clinical trials. The pathophysiology of IIH is incompletely characterised; suggested underpinning mechanisms include the role of cerebrospinal fluid regulation as well as metabolic and endocrinological perspectives. Recent treatment trials are providing insights into the management but debate still surrounds key areas in treatment. This review will provide an up-to-date discussion on the potential pathogenic mechanisms and management of IIH.
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