Antagonist Impact of Selenium-Based Nanoparticles Against Mycobacterium tuberculosis

One of the cardinal causes of global deaths from a single-point infectious agent has been reported to be tuberculosis (or TB). At present times, the incidence of TB cases occurs mostly due to multi-drug resistance, which is expected to boost further in the upcoming times. Accordingly, the development of alternative treatment methodologies has received significant research interest. In this regard, the application of nanoparticles has notable cognizance. The literature suggested that nanoparticles have substantial potential to be used as the delivery medium for drug injection as well as they also serve as a potential bactericidal agent. In this present study, the efficacy of the selenium nanoparticles against the inhibition of growth of Mycobacterium tuberculosis was evaluated. The obtained results indicated that the synthesized selenium nanoparticles have notable cognizance towards the inhibition of growth of Mycobacterium tuberculosis by disrupting the integrity of their cell envelope. This study thus proposes a novel approach and opens new dimensional avenues in the field of nanoparticle-induced cell disruption strategies.

Automated summary

Tuberculosis (TB) has been identified as a major cause of global deaths from a single-point infectious agent, mainly due to multi-drug resistance. As a result, there is significant research interest in developing alternative treatment methodologies. The application of nanoparticles has been found to have substantial potential as a delivery medium and bactericidal agent. This study evaluated the efficacy of selenium nanoparticles in inhibiting the growth of Mycobacterium tuberculosis, and the results showed that the synthesized selenium nanoparticles disrupted the integrity of the cell envelope and effectively inhibited its growth. This study proposes a novel approach and opens new avenues in nanoparticle-induced cell disruption strategies.