Journal
ANTICANCER RESEARCH
Volume 42, Issue 12, Pages 5927-5935Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.16102
Keywords
Epithelial-mesenchymal transition; colon cancer; lymph node metastasis; SNAI1; SNAIL
Categories
Funding
- Japan Society for the Promotion of Science [18K07194, 19K09114, 20K09051, 20K21626, 21H02778]
- Japan Agency for Medical Research and Development (AMED) [JP 19cm0106502]
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This study investigated the expression differences of SNAI1 and E-cadherin in primary tumors and LNMs of colon adenocarcinoma, and their impact on prognosis. The results showed that high expression of SNAI1 in LNMs was significantly correlated with poor prognosis, while low SNAI1 expression may indicate delayed recurrence in the liver and lung.
Background/Aim: Even though epithelial- mesenchymal transition markers in primary tumors are identified as a helpful indicator of cancer metastasis and prognosis, their expression in lymph node metastases (LNMs) remains poorly described. We aimed to investigate the difference between snail family transcriptional repressor 1 (SNAI1) and E-cadherin expression in primary tumors and LNMs, and how it affects prognosis. Patients and Methods: From 2010 to 2014, 127 patients who underwent radical surgery for stage III colonic adenocarcinoma without preoperative treatment were retrospectively reviewed for SNAI1 and E-cadherin expression in primary tumors and LNMs. Results: High SNAI1 expression was found in 76% and 70% of primary tumors and LNMs, respectively, and low E-cadherin expression was found in 73% and 84%, respectively. High expression of SNAI1 in LNMs significantly correlated with poor overall and relapse-free survival rates. Even though the rate of liver metastasis at 5 years was similar for the groups with high and low SNAI1 expression in LNMs, the incidence in the group with low SNAI1 expression in the second year was higher than that in the first year (33% vs. 17%), whilst in the group with high SNAI1 expression, the incidence in the first year was higher than in the second year (71% vs. 29%). The rate of recurrence of lung metastasis was significantly lower when SNAI1 expression in LNMs was low (p=0.031). Conclusion: Low expression of SNAI1 in LNMs of colonic adenocarcinoma may indicate delayed recurrence in the liver and lung.
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