Journal
ANTICANCER RESEARCH
Volume 42, Issue 11, Pages 5587-5595Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.16066
Keywords
Rectal cancer; accelerated hyperfractionated radiotherapy; preoperative radiotherapy; neoadjuvant radiotherapy; short-course radiotherapy; capecitabine; S-1; chemotherapy; radiotherapy
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Funding
- JSPS KAKENHI
- [JP20K08093]
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This study assessed the clinical outcomes of neoadjuvant modified short-course radiotherapy (mSC-RT) for rectal metastatic adenocarcinoma. The results showed that delayed surgery after mSC-RT led to good local control, but some patients experienced local failures and death during the follow-up period.
Background/Aim: This study aimed to assess the clinical outcomes of neoadjuvant modified short-course radiotherapy (mSC-RT) for rectal metastatic adenocarcinoma. Patients and Methods: Data from 14 patients who underwent mSC-RT followed by surgery for primary tumors were retrospectively analyzed. Twelve patients received systemic chemotherapy for 18 weeks. A 2.5 Gy dose twice daily, up to a total dose of 25 Gy in 10 fractions, over 5 consecutive days was administered through mSC-RT. Surgery for primary tumor was performed five weeks (range=3-7 weeks) after mSC-RT. Nine patients underwent adjuvant chemotherapy. The median follow-up was 38.5 months. Results: No patients developed grade >= 3 toxicities before surgery. Three patients developed local failures and 10 died during the follow-up period. The 1-, and 3-year local control rates were 91.7% and 71.3%, respectively. The median overall survival (OS) was 45.1 months. The 1-, and 3-year OS rates were 85.7% and 56.3%, respectively. Patients with stage IVA showed significantly better OS than those with stage IVB disease. Conclusion: mSC-RT followed by delayed surgery was well-tolerated and led to good local control in patients with rectal metastatic
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