Immune-Epithelial Cross Talk in Regeneration and Repair

Article Immunology

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

Xun Lin et al.

Summary: IL-17A plays a crucial role in the differentiation of secretory epithelial cells in the gut, maintaining the integrity and health of the mucosa by regulating the cross talk between intestinal cells.

IMMUNITY (2022)

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Article Multidisciplinary Sciences

CAR T cells produced in vivo to treat cardiac injury

Joel G. Rurik et al.

Summary: This study developed a therapeutic approach to generate antifibrotic CAR T cells in vivo by delivering modified mRNA in T cell-targeted nanoparticles. The efficacy of these in vivo-reprogrammed CAR T cells was evaluated in a mouse model of heart failure.

SCIENCE (2022)

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Review Neurosciences

Neuroimmune Interactions in Peripheral Organs

Roel G. J. Klein Wolterink et al.

Summary: Interactions between the nervous and immune systems are more frequent than previously thought, occurring at different anatomical locations and affecting multiple physiological processes. Understanding these interactions is crucial for exploring therapeutic potential.

ANNUAL REVIEW OF NEUROSCIENCE (2022)

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Article Cell Biology

Epithelial-immune crosstalk in health and disease

Daniel Rosenblum et al.

Summary: The dynamic crosstalk between our body's epithelial boundaries and immune cells is crucial for immune surveillance and barrier function. This review focuses on the interactions between immune cells and epithelial subsets in the skin and gut epithelium, two important environmental interfaces. The communication between immune cells and epithelial progenitors and the exchanges between differentiated epithelial subsets and adjacent immune cells are discussed. Therapeutic targeting of stage-specific immune-epithelial interaction has the potential to enhance tissue regeneration and reduce inflammatory pathologies.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

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Article Dermatology

Single-Cell Analysis Reveals Major Histocompatibility Complex II-Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes

Dongqing Li et al.

Summary: This study compared the single-cell transcriptomic profiles of epidermal cells from pressure ulcer (PU) wounds with those from acute wounds and uninjured skin. The researchers identified significant shifts in cell composition and gene expression patterns in PU. They also found that patients with worse healing outcomes had an enrichment of major histocompatibility complex class II-expressing keratinocytes. Furthermore, the study showed that IFN-gamma in PU-derived wound fluid could induce major histocompatibility complex II expression in keratinocytes, which inhibited autologous T-cell activation. T cells from PUs with major histocompatibility complex II+ keratinocytes produced fewer inflammatory cytokines. The study provides insights into PU pathology and the future development of tailored wound therapy.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Immunology

Neutrophils direct preexisting matrix to initiate repair in damaged tissues

Adrian Fischer et al.

Summary: Research shows that damaged organs can repair wounds by transferring preexisting matrix through neutrophils. The source of the transferred matrix may determine the scarring or regeneration of the healing tissue. Blocking this transfer process through pharmacological inhibition can prevent matrix transfer and the formation of peritoneal adhesions.

NATURE IMMUNOLOGY (2022)

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Article Cell & Tissue Engineering

Lymphatics act as a signaling hub to regulate intestinal stem cell activity

Rachel E. Niec et al.

Summary: This study reveals a lymphatic network associated with intestinal stem cells (ISCs) in the small and large intestines. The crypt lymphatics maintain ISCs and prevent their premature differentiation. Using single-cell and spatial transcriptomics, lymphatics are identified as a central signaling hub for the crypt and ISCs.

CELL STEM CELL (2022)

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Article Multidisciplinary Sciences

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Elisabeth Serger et al.

Summary: Intermittent fasting promotes axonal regeneration and accelerates recovery of sensory function after sciatic nerve injury in mice, relying on the gram-positive gut microbiome and the increase in the gut bacteria-derived metabolite indole-3-propionic acid (IPA). This effect is mediated by neutrophil chemotaxis.

NATURE (2022)

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Article Immunology

Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche

Zhi Liu et al.

Summary: This study reveals the interaction between T-reg cells and HFSCs, which is mediated by the glucocorticoid receptor signaling pathway and TGF-beta 3, promoting HFSC proliferation and skin regeneration.

NATURE IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Interleukin-17 governs hypoxic adaptation of injured epithelium

Piotr Konieczny et al.

Summary: Mammalian cells activate HIFs to survive in low-oxygen environments, but injury-induced hypoxia is unable to activate HIF1 alpha. However, IL-17A derived from ROR gamma t(+) gamma delta T cells can activate HIF1 alpha. The IL-17A-HIF1 alpha axis promotes glycolysis for wound healing in epithelial cells, and loss of IL-17RC, HIF1 alpha, or blockade of glycolysis disrupts the repair process. These findings highlight the interconnectedness of inflammation, metabolism, and migration programs, as well as the role of immune cell-derived inputs in cellular adaptation to hypoxic stress during repair.

SCIENCE (2022)

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Article Biology

Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

Zhuang Liu et al.

Summary: This study identified 17 pathologically relevant miRNAs that are involved in chronic wound pathology and showed their high cooperativity. By targeting these miRNAs, innovative wound treatments with higher efficacy and specificity could be developed.

ELIFE (2022)

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Article Developmental Biology

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart

Thomas J. Cahill et al.

Summary: Macrophages play an essential role in supporting lymphatic growth during mammalian cardiac vasculature development, regulating lymphatic endothelial cell remodeling through direct interactions. Global macrophage deficiency results in shortened, mis-patterned lymphatics, and the origin of cardiac macrophages is linked to the yolk sac and fetal liver.

DEVELOPMENT (2021)

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Article Multidisciplinary Sciences

Developmental cell programs are co-opted in inflammatory skin disease

Gary Reynolds et al.

Summary: The skin establishes a complex cellular network early in embryonic development to provide biophysical and immunological protection. The study found an enrichment of innate immune cells in skin during the first trimester, as well as clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. Additionally, a reemergence of prenatal vascular endothelial cell and macrophage cellular programs was observed in atopic dermatitis and psoriasis lesional skin.

SCIENCE (2021)

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Review Immunology

Immunosensation: Neuroimmune Cross Talk in the Skin

Masato Tamari et al.

Summary: Traditionally seen as a mere structural barrier, the skin is now recognized as a complex immunological barrier involved in antimicrobial immunity and wound healing, housing a sophisticated sensory network to sense various stimuli. Recent studies suggest that the skin's nervous system is integrated with the immune system to encode specific sensations into protective behaviors, showcasing a dynamic and systemic organ with coordinated physical, immunological, and neural functions.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

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Article Multidisciplinary Sciences

Regulation of intestinal immunity and tissue repair by enteric glia

Franze Progatzky et al.

Summary: Enteric glial cells play important roles in immune regulation and tissue repair in the mouse intestine, with IFN gamma signaling being central to intestinal homeostasis and tissue repair. The gliosis and upregulation of specific genes in enteric glial cells contribute to immune homeostasis and tissue repair after parasite infection-induced intestinal damage.

NATURE (2021)

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Article Immunology

The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

Robert A. Saxton et al.

Summary: This study engineered a high-affinity IL-22 superagonist to investigate the molecular mechanisms of the IL-22 signaling pathway. They found that precise control of IL-22 signaling can be achieved by modulating receptor expression levels and signaling bias, leading to tissue protection effects.

IMMUNITY (2021)

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Review Immunology

Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer

Matthew B. Buechler et al.

Summary: Fibroblasts and macrophages are able to communicate directly in tissues, influencing the microenvironment and disease outcomes. Their interactions play a significant role in health, fibrosis, and cancer, with effects influenced by tissue and context, as well as cell origin and state.

IMMUNITY (2021)

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Article Multidisciplinary Sciences

Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions

Guillaume Hoeffel et al.

Summary: This study investigated the role of sensory neurons in promoting the tissue-repair function of macrophages and uncovered the regulatory mechanism of the neuropeptide TAFA4 on macrophage inflammatory responses. TAFA4, produced by a subset of sensory neurons, modulates the inflammatory profile of macrophages and promotes the production of IL-10 after skin damage in mice. This neuroimmune regulatory pathway driven by TAFA4 helps prevent fibrosis and promotes tissue regeneration, presenting new therapeutic perspectives for inflammatory diseases.

NATURE (2021)

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Article Multidisciplinary Sciences

A molecular single-cell lung atlas of lethal COVID-19

Johannes C. Melms et al.

Summary: Single-nucleus RNA sequencing of lung tissues from individuals who died of COVID-19 revealed a highly inflamed lung environment with impaired T cell responses and failed transition of alveolar type 2 cells. Additionally, expansion of pathological fibroblasts contributing to rapidly ensuing pulmonary fibrosis in COVID-19 was identified as a unique feature compared to other causes of pneumonia.

NATURE (2021)

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Article Multidisciplinary Sciences

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Toni M. Delorey et al.

Summary: This study using single-cell and spatial atlases revealed the impact of COVID-19 infection on lung, kidney, liver, and heart tissues, showing structural remodeling and viral RNA enrichment. Differences in lung inflammatory responses and transcriptional alterations in heart tissue of COVID-19 patients were also identified, along with cell types and genes associated with disease severity.

NATURE (2021)

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Editorial Material Multidisciplinary Sciences

Healing without scarring

Piotr Konieczny et al.

Summary: The study identified a crucial gene regulatory circuit that guides tissue regeneration and prevents fibrosis.

SCIENCE (2021)

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Review Immunology

Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin

Karina Hadrian et al.

Summary: Macrophages play a critical role in tissue vascularization in both health and disease contexts. Understanding the mechanisms of macrophage-mediated blood and lymphatic vessel growth in different tissues can provide insights into potential therapeutic interventions for various diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Fibroblasts: Origins, definitions, and functions in health and disease

Maksim Plikus et al.

Summary: Fibroblasts are diverse mesenchymal cells that play a role in tissue homeostasis and disease, producing complex extracellular matrix and creating signaling niches. They are transcriptionally and functionally heterogeneous across and within organs, encoding positional information and maintaining distinct cellular progeny. Their unique properties make them poised for tissue repair but can also drive fibrotic disorders if activated aberrantly.

CELL (2021)

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Article Cell Biology

Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells

Jin Li et al.

Summary: Research has shown that lymphatic endothelial cells highly express neurotensin, with its expression being influenced by cold and norepinephrine to regulate adipose tissue thermogenesis. Treatment with NTS can decrease the expression of thermogenic genes in brown adipose tissue. Furthermore, NTS affects cold tolerance and energy expenditure through NTSR2 and ERK signaling pathways.

CELL METABOLISM (2021)

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Article Cell & Tissue Engineering

Establishment, maintenance, and recall of inflammatory memory

Samantha B. Larsen et al.

Summary: The research explains how cells establish, maintain, and recall inflammatory memory, revealing the collaboration between factors like FOS and JUN, and their crucial role in re-recruiting and activating genes under diverse secondary challenges.

CELL STEM CELL (2021)

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Article Multidisciplinary Sciences

Cells of the human intestinal tract mapped across space and time

Rasa Elmentaite et al.

Summary: The study analyzes cells from various stages of human development along the intestinal tract, revealing transcriptionally distinct BEST4 epithelial cells and implicating IgG sensing as a function of tuft cells. It also describes neural cell populations in the developing enteric nervous system and identifies key players in the formation of lymphoid tissue in early human development and inflammatory bowel disease.

NATURE (2021)

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Article Multidisciplinary Sciences

Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

Ai Ing Lim et al.

Summary: Research suggests that maternal restricted infection during pregnancy can have permanent and tissue-specific impacts on offspring immunity, with maternal interleukin-6 playing a key role in this process. This may indicate that maternal infection can affect fetal intestinal immune homeostasis, leading to altered inflammatory immune responses in offspring.

SCIENCE (2021)

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Article Immunology

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation

Joshua M. Moreau et al.

Summary: Skin T-regs play a crucial role in regulating inflammation and protecting skin immunity, influencing epithelial cell biology through integrin and TGF-beta pathways. After skin injury, they activate TGF-beta and promote inflammation responses to protect the host from infection.

SCIENCE IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

Fanny Matheis et al.

CELL (2020)

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Article Immunology

The development of colitis in Il10-/- mice is dependent on IL-22

Dilini C. Gunasekera et al.

MUCOSAL IMMUNOLOGY (2020)

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Article Cell Biology

Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells

Monica Romera-Hernandez et al.

CELL REPORTS (2020)

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Article Cell & Tissue Engineering

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

Brett A. Shook et al.

CELL STEM CELL (2020)

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Review Immunology

Neuro-immune Interactions in the Tissues

Coco Chu et al.

IMMUNITY (2020)

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Article Biochemistry & Molecular Biology

Neutrophils Modulate Fibroblast Function and Promote Healing and Scar Formation after Murine Myocardial Infarction

Adelina Curaj et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics

Daniel Haensel et al.

CELL REPORTS (2020)

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Review Rheumatology

Paradoxical gastrointestinal effects of interleukin-17 blockers

Marine Fauny et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Review Biochemistry & Molecular Biology

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

Guillermo Oliver et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

Emanuela Pasciuto et al.

CELL (2020)

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Review Immunology

The Many Functions of Foxp3+ Regulatory T Cells in the Intestine

Catalina Cosovanu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Lymphoangiocrine signals promote cardiac growth and repair

Xiaolei Liu et al.

NATURE (2020)

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Article Hematology

Macrophage ferroportin is essential for stromal cell proliferation in wound healing

Stefania Recalcati et al.

HAEMATOLOGICA (2019)

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Article Cell & Tissue Engineering

A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

Etienne C. E. Wang et al.

CELL STEM CELL (2019)

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Article Immunology

Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Anubhav N. Mathur et al.

IMMUNITY (2019)

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Article Immunology

Innate Control of Tissue-Reparative Human Regulatory T Cells

Avery J. Lam et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Biology

Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development

David A. D. Munro et al.

ELIFE (2019)

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Article Oncology

T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis

Christophe Cataisson et al.

MOLECULAR CANCER RESEARCH (2019)

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Article Immunology

IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response

Biana Bernshtein et al.

SCIENCE IMMUNOLOGY (2019)

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Article Hematology

Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC

Lillian Lim et al.

BLOOD (2019)

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Article Biochemistry & Molecular Biology

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

Yi Wang et al.

CELL (2019)

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Article Multidisciplinary Sciences

Patch repair of deep wounds by mobilized fascia

Donovan Correa-Gallegos et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Stem cell-driven lymphatic remodeling coordinates tissue regeneration

Shiri Gur-Cohen et al.

SCIENCE (2019)

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Article Immunology

IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells

Xing Chen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Gastroenterology & Hepatology

Tales from the crypt: new insights into intestinal stem cells

Helmuth Gehart et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

Oliver J. Harrison et al.

SCIENCE (2019)

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Article Immunology

Heterogeneity of neutrophils

Lai Guan Ng et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Engineering, Biomedical

CD4 T-cells regulate angiogenesis and myogenesis

Brian J. Kwee et al.

BIOMATERIALS (2018)

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Article Biochemistry & Molecular Biology

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Jonathan L. Linehan et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

David B. Gurevich et al.

EMBO JOURNAL (2018)

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Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

CELL (2018)

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Article Immunology

Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis

Jason E. Hawkes et al.

JOURNAL OF IMMUNOLOGY (2018)

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Review Endocrinology & Metabolism

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Claudio Franceschi et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

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Article Biochemistry & Molecular Biology

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

Moshe Biton et al.

CELL (2018)

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Article Biology

Stem cells repurpose proliferation to contain a breach in their niche barrier

Kenneth Lay et al.

ELIFE (2018)

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Article Cell Biology

Alerting the Body to Tissue Injury: The Role of Alarmins and DAMPs in Cutaneous Wound Healing

Traci A. Wilgus

CURRENT PATHOBIOLOGY REPORTS (2018)

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Article Biochemistry & Molecular Biology

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium

Hiroyuki Miyoshi et al.

EMBO JOURNAL (2017)

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Review Immunology

Homeostatic Immunity and the Microbiota

Yasmine Belkaid et al.

IMMUNITY (2017)

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Article Medicine, Research & Experimental

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling

Miguel Quiros et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Multidisciplinary Sciences

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

Shruti Naik et al.

NATURE (2017)

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Review Immunology

Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation

Felipe A. Pinho-Ribeiro et al.

TRENDS IN IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Xusheng Wang et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

Mariaceleste Aragona et al.

NATURE COMMUNICATIONS (2017)

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Review Oncology

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

Ping Wee et al.

CANCERS (2017)

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Article Cell & Tissue Engineering

Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls

Donald M. Bryant et al.

NPJ REGENERATIVE MEDICINE (2017)

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Article Cell & Tissue Engineering

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

Samantha Haller et al.

CELL STEM CELL (2017)

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Review Biology

Tissue macrophages: heterogeneity and functions

Siamon Gordon et al.

BMC BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Niwa Ali et al.

CELL (2017)

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Review Biochemistry & Molecular Biology

Neuro-Immune Interactions at Barrier Surfaces

Henrique Veiga-Fernandes et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin

Brice E. Keyes et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

Ilana Gabanyi et al.

CELL (2016)

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Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

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Article Immunology

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

Audrey Nosbaum et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

Sales Ibiza et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

Subhrajit Saha et al.

NATURE COMMUNICATIONS (2016)

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Review Immunology

Interleukin-22: Immunobiology and Pathology

Jarrod A. Dudakov et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

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Article Immunology

Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage

Xinyang Song et al.

IMMUNITY (2015)

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Review Immunology

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

Ari B. Molofsky et al.

IMMUNITY (2015)

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Article Immunology

Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

Patricia Aparicio-Domingo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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Article Multidisciplinary Sciences

Commensal-dendritic-cell interaction specifies a unique protective skin immune signature

Shruti Naik et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Caroline A. Lindemans et al.

NATURE (2015)

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Article Multidisciplinary Sciences

A gp130-Src-YAP module links inflammation to epithelial regeneration

Koji Taniguchi et al.

NATURE (2015)

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Article Biochemistry & Molecular Biology

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Siu Ling Wong et al.

NATURE MEDICINE (2015)

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Article Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

Heitor S. P. de Souza et al.

Nature Reviews Gastroenterology & Hepatology (2015)

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Review Pathology

Epithelial Cell Shedding and Barrier Function: A Matter of Life and Death at the Small Intestinal Villus Tip

J. M. Williams et al.

VETERINARY PATHOLOGY (2015)

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Review Immunology

Regulation of macrophage development and function in peripheral tissues

Yonit Lavin et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Immunology

Immunology of Psoriasis

Michelle A. Lowes et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Article Gastroenterology & Hepatology

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen

Gianluca Matteoli et al.

GUT (2014)

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Review Immunology

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray et al.

IMMUNITY (2014)

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Article Immunology

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

Ilona Kryczek et al.

IMMUNITY (2014)

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Article Immunology

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

Eric L. Campbell et al.

IMMUNITY (2014)

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Article Multidisciplinary Sciences

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Chris Schiering et al.

NATURE (2014)

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Review Biochemistry & Molecular Biology

Emerging interactions between skin stem cells and their niches

Ya-Chieh Hsu et al.

NATURE MEDICINE (2014)

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Article Medicine, General & Internal

Secukinumab in Plaque Psoriasis - Results of Two Phase 3 Trials

Richard G. Langley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Multidisciplinary Sciences

IL-6 Stimulates Intestinal Epithelial Proliferation and Repair after Injury

Kristine A. Kuhn et al.

PLOS ONE (2014)

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Article Biochemistry & Molecular Biology

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

Donatello Castellana et al.

PLOS BIOLOGY (2014)

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Article Dermatology

The Role of Hypoxia-Inducible Factor in Wound Healing

Wan Xing Hong et al.

ADVANCES IN WOUND CARE (2014)

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Review Dermatology

Epithelialization in Wound Healing: A Comprehensive Review

Irena Pastar et al.

ADVANCES IN WOUND CARE (2014)

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Article Biochemistry & Molecular Biology

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Dalia Burzyn et al.

CELL (2013)

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Article Gastroenterology & Hepatology

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

Christopher J. Moran et al.

INFLAMMATORY BOWEL DISEASES (2013)

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Article Immunology

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

Stefanie Kirchberger et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Multidisciplinary Sciences

M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis

Jesus Cosin-Roger et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Macrophages are required for adult salamander limb regeneration

James W. Godwin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Dermatology

Effects of immunosuppressive therapy on wound healing

Roshan Bootun

INTERNATIONAL WOUND JOURNAL (2013)

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Article Hematology

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

Sebastian Willenborg et al.

BLOOD (2012)

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Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factors in Physiology and Medicine

Gregg L. Semenza

CELL (2012)

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Article Multidisciplinary Sciences

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Sergei I. Grivennikov et al.

NATURE (2012)

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Article Immunology

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

Keisuke Nagao et al.

NATURE IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Shiro Yui et al.

NATURE MEDICINE (2012)

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Article Multidisciplinary Sciences

Compartmentalized Control of Skin Immunity by Resident Commensals

Shruti Naik et al.

SCIENCE (2012)

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Article Cardiac & Cardiovascular Systems

Critical role of Th17 cells in inflammation and neovascularization after ischaemia

Takeki Hata et al.

CARDIOVASCULAR RESEARCH (2011)

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Letter Dermatology

A Wound Size-Dependent Effect of Myeloid Cell-Derived Vascular Endothelial Growth Factor on Wound Healing

Christian Stockmann et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Article Immunology

Differential Roles of Macrophages in Diverse Phases of Skin Repair

Tina Lucas et al.

JOURNAL OF IMMUNOLOGY (2010)

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