Risk stratification of sudden cardiac death in asymptomatic female Brugada syndrome patients: A literature review

Background and ObjectivesRisk stratification in Brugada syndrome remains a difficult problem. Given the male predominance of this disease and their elevated risks of arrhythmic events, affected females have received less attention. It is widely known that symptomatic patients are at increased risk of sudden cardiac death (SCD) than asymptomatic patients, while this might be true in the male population; recent studies have shown that this association might not be significant in females. Over the past few decades, numerous markers involving clinical symptoms, electrocardiographic (ECG) indices, and genetic tests have been explored, with several risk-scoring models developed so far. The objective of this study is to review the current evidence of clinical and ECG markers as well as risk scores on asymptomatic females with Brugada syndrome. FindingsGender differences in ECG markers, the yield of genetic findings, and the applicability of risk scores are highlighted. ConclusionsVarious clinical, electrocardiographic, and genetic risk factors are available for assessing SCD risk amongst asymptomatic female BrS patients. However, due to the significant gender discrepancy in BrS, the SCD risk amongst females is often underestimated, and there is a lack of research on female-specific risk factors and multiparametric risk scores. Therefore, multinational studies pooling female BrS patients are needed for the development of a gender-specific risk stratification approach amongst asymptomatic BrS patients.

Automated summary

Risk stratification in Brugada syndrome remains a challenge, with less attention given to affected females. Recent studies have shown that the association between symptoms and sudden cardiac death may not be significant in females. Various clinical, electrocardiographic, and genetic risk factors for assessing sudden cardiac death risk in asymptomatic female Brugada syndrome patients have been identified, but there is a lack of research on female-specific risk factors and multiparametric risk scores.