☆ 4.7 Article

Atrophy of the Cholinergic Basal Forebrain can Detect Presynaptic Cholinergic Loss in Parkinson's Disease

ANNALS OF NEUROLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Clinical Neurology

Altered Cholinergic Innervation in De Novo Parkinson's Disease with and without Cognitive Impairment

Sygrid van der Zee et al.

Summary: This study assessed the cholinergic innervation status in early-stage Parkinson's disease (PD) patients and found that cholinergic innervation changes were associated with cognitive impairment. Regardless of cognitive status, patients showed cholinergic denervation in the posterior cortical regions. Cognitively intact patients exhibited higher cholinergic activity in the cerebellar, frontal, and subcortical regions, suggesting compensatory cholinergic upregulation in early-stage PD. Limited or failing cholinergic upregulation may play an important role in early cognitive impairment in PD.

MOVEMENT DISORDERS (2022)

Add to Collection

Article Clinical Neurology

Progression of regional cortical cholinergic denervation in Parkinson's disease

Nicolaas Bohnen et al.

Summary: This study presents the first longitudinal cholinergic PET study in the Parkinson's population. The findings suggest a posterior-to-anterior denervation gradient in the posterior cortices and an anterior-to-posterior gradient in the frontal cortices, which are associated with changes in blood flow. These results contribute to our understanding of the cognitive decline and other deficits in Parkinson's disease related to cortical cholinergic deficits. The importance of this study is rated 8 out of 10.

BRAIN COMMUNICATIONS (2022)

Add to Collection

Article Clinical Neurology

Normal cognition in Parkinson's disease may involve hippocampal cholinergic compensation: An exploratory PET imaging study with [18F]-FEOBV

Camille Legault-Denis et al.

Summary: This study found that in Parkinson's disease, compensatory upregulation of hippocampal cholinergic innervation was only present in cognitively normal patients (PD-CN), which may contribute to maintaining normal cognitive performance.

PARKINSONISM & RELATED DISORDERS (2021)

Add to Collection

Review Clinical Neurology

Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views

Prabesh Kanel et al.

Summary: This study reviewed brain cholinergic denervation in AD and DLB patients using molecular imaging, revealing distinct cortical and subcortical cholinergic lesions that can differentiate between the two types of dementia. The differential vulnerability of specific cholinergic projections may be associated with specific clinical features of these disorders, offering potential for symptomatic therapies through improved understanding of cholinergic deficits in the brain region.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2021)

Add to Collection

Article Clinical Neurology

FEOBV-PET to quantify cortical cholinergic denervation in AD: Relationship to basal forebrain volumetry

Meghmik Aghourian et al.

Summary: This study aimed to validate the reliability of quantifying cholinergic denervation in Alzheimer's disease using [F-18]-FEOBV PET, by demonstrating its concordance with MRI volumetry of the cholinergic basal forebrain. The results showed lower ChBF-Ch4 volumetric values and [F-18]-FEOBV cortical uptake in AD patients compared to healthy volunteers, suggesting a proportional relationship between cortical cholinergic denervation and ChBF atrophy.

JOURNAL OF NEUROIMAGING (2021)

Add to Collection

Article Clinical Neurology

In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study

Michel J. Grothe et al.

Summary: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration.

PARKINSONISM & RELATED DISORDERS (2021)

Add to Collection

Article Clinical Neurology

Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson's disease

Nicolaas Bohnen et al.

Summary: The study found that in Parkinson's disease patients, cholinergic brain regions associated with postural instability and gait difficulties include the medial geniculate nucleus, lateral geniculate nucleus, and entorhinal cortex. Cholinergic brain regions associated with tremor domain included the cerebellar vermis section of lobule VIIIb and the putamen. For the distal limb bradykinesia domain, cholinergic brain regions included the globus pallidus pars externa and the paracentral lobule.

BRAIN COMMUNICATIONS (2021)

Add to Collection

Article Clinical Neurology

Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease

Sygrid van der Zee et al.

Summary: This study investigated the relationship between cognitive functioning and regional cholinergic innervation in patients with PD, utilizing [F-18]Fluoroethoxybenzovesamicol positron emission tomography imaging. The results showed partial overlapping topography across cognitive domains, with most robust correlations in the domains of memory, attention, and executive functioning. The findings confirm and expand on previous observations of cholinergic system involvement in cognitive functioning in PD, reflecting a combination of disease-specific and aging effects.

MOVEMENT DISORDERS (2021)

Add to Collection

Article Clinical Neurology

Topography of Cholinergic Changes in Dementia With Lewy Bodies and Key Neural Network Hubs

Prabesh Kanel et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2020)

Add to Collection

Article Neurosciences

Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease

Joana B. Pereira et al.

NEUROBIOLOGY OF DISEASE (2020)

Add to Collection

Letter Biochemistry & Molecular Biology

Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV

Siamak Nejad-Davarani et al.

MOLECULAR PSYCHIATRY (2019)

Add to Collection

Article Clinical Neurology

Cholinergic system changes of falls and freezing of gait in Parkinson's disease

Nicolaas Bohnen et al.

ANNALS OF NEUROLOGY (2019)

Add to Collection

Letter Clinical Neurology

[18F]Fluoroethoxybenzovesamicol in Parkinson's disease patients: Quantification of a novel cholinergic positron emission tomography tracer

Sygrid van der Zee et al.

MOVEMENT DISORDERS (2019)

Add to Collection

Article Clinical Neurology

Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease

Jonathan Schulz et al.

BRAIN (2018)

Add to Collection

Article Anatomy & Morphology

Basal Forebrain Nuclei Display Distinct Projecting Pathways and Functional Circuits to Sensory Primary and Prefrontal Cortices in the Rat

Irene Chaves-Coira et al.

FRONTIERS IN NEUROANATOMY (2018)

Add to Collection

Article Clinical Neurology

In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson's disease

Nicola J. Ray et al.

BRAIN (2018)

Add to Collection

Review Clinical Neurology

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease

Alan King Lun Liu et al.

ACTA NEUROPATHOLOGICA (2015)

Add to Collection

Article Clinical Neurology

Clinical Markers for Identifying Cholinergic Deficits in Parkinson's Disease

Martijn L. T. M. Mueller et al.

MOVEMENT DISORDERS (2015)

Add to Collection

Article Neurosciences

Subregional Basal Forebrain Atrophy in Alzheimer's Disease: A Multicenter Study

Ingo Kilimann et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Add to Collection

Article Endocrinology & Metabolism

Heterogeneity of cholinergic denervation in Parkinson's disease without dementia

Nicolaas I. Bohnen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Add to Collection

Article Biochemical Research Methods

Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [18F]labelled radiopharmaceuticals using a Tracerlab FXFN

Xia Shao et al.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2011)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Cerebral Glucose Metabolic Features of Parkinson Disease and Incident Dementia: Longitudinal Study

Nicolaas I. Bohnen et al.

JOURNAL OF NUCLEAR MEDICINE (2011)

Add to Collection

Article Clinical Neurology

Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo

J. C. Klein et al.

NEUROLOGY (2010)

Add to Collection

Article Neurosciences

A fast diffeomorphic image registration algorithm

John Ashburner

NEUROIMAGE (2007)

Add to Collection

Review Neurosciences

Ageing and neuronal vulnerability

MP Mattson et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Add to Collection

Review Endocrinology & Metabolism

Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease

Nicolaas I. Bohnen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2006)

Add to Collection

Article Clinical Neurology

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

ST DeKosky et al.

ANNALS OF NEUROLOGY (2002)

Add to Collection

Review Ophthalmology

Macular microcirculation characteristics in Parkinson's disease evaluated by OCT-Angiography: a literature review

Evita Evangelia Christou et al.

Summary: The retina may serve as a predictive factor for neurodegenerative disorders, with recent use of Optical Coherence Tomography Angiography (OCT-A) in studying macular microcirculation changes in Parkinson's disease (PD). While preliminary evidence suggests OCT-A could be a useful biomarker for cerebral vasculature in PD, further research is needed to confirm its predictive value in clinical practice.

SEMINARS IN OPHTHALMOLOGY

Add to Collection

© Peeref 2019-2024. All rights reserved.