Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 62, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202217735
Keywords
1; 3-Dienes; Hydromagnesiation; Magnesium Hydride; Sodium Hydride
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A protocol was developed to generate allylmagnesium reagents from 2-aryl-1,3-dienes using in situ generated magnesium hydride (MgH2) through solvothermal treatment of sodium hydride (NaH) and magnesium iodide (MgI2) in tetrahydrofuran (THF). Downstream functionalization of the resulting allylmagnesium reagents with carbonyl compounds or alkyl (pseudo)halides led to branched products with an allylic quaternary carbon center, while reaction with chlorosilanes resulted in regio and stereoselective formation of linear allylsilanes. Further derivatizations of the homoallylic alcohols and allylsilanes were also demonstrated.
A protocol for the generation of allylmagnesium reagents from 2-aryl-1,3-dienes was developed using magnesium hydride (MgH2) that is generated in situ by solvothermal treatment of sodium hydride (NaH) and magnesium iodide (MgI2) in tetrahydrofuran (THF). Downstream functionalization of the resulting allylmagnesium reagents with carbonyl compounds or alkyl (pseudo)halides delivers branched products having an allylic quaternary carbon center, whereas that with chlorosilanes resulted in formation of linear allylsilanes in regio and stereoselective manners. Further derivatizations of the homoallylic alcohols and allylsilanes were also demonstrated.
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