4.8 Article

Ultrasensitive Fluorescence Detection and Imaging of MicroRNA in Cells Based on a Hyperbranched RCA-Assisted Multiposition SDR Signal Amplification Strategy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Color-Changing Fluorescent Barcode Based on Strand Displacement Reaction Enables Simple Multiplexed Labeling

Koki Makino et al.

Summary: This study presents a color-changing fluorescent barcode (CCFB) approach that allows for multiple labeling with a simple nucleic acid structure design. The CCFB method is easy to operate and time-saving, and has been successfully used for labeling multiple targets and detecting intracellular proteins.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Chemistry, Analytical

Endogenous MicroRNA Accurate Diagnostics to Guide Photothermal Therapy

Fan Yang et al.

Summary: This study developed a smart nanodevice for accurate diagnosis of endogenous cancer biomarkers and efficient photothermal therapy. The device demonstrated high sensitivity in biomarker detection and promising therapeutic efficacy.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Analytical

A Sample and Detection Microneedle Patch for Psoriasis MicroRNA Biomarker Analysis in Interstitial Fluid

Yuchun Qiao et al.

Summary: This study developed microneedles made of gelatin methacryloyl and graphene oxide for the enrichment and sensitive detection of multiple microRNA biomarkers from skin interstitial fluid. The microneedles exhibited robust mechanical properties and fast sampling kinetics, enabling effective miRNA analysis and personalized diagnosis.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Analytical

Catalytic Hairpin Assembly-Driven Ratiometric Dual-SignalElectrochemical Biosensor for Ultrasensitive Detection of MicroRNABased on the Ratios of Fe-MOFs and MB-GA-UiO-66-NH2

Jiangbo Dong et al.

Summary: In this work, a novel ratio electrochemical biosensing platform based on catalytic hairpin assembly target recovery was developed for ultrasensitive detection of microRNA (miRNA). The platform showed excellent detection performance in complex serum environments and tumor cell lysates, making it highly potential for biosensing and clinical diagnosis.

ANALYTICAL CHEMISTRY (2022)

Article Chemistry, Analytical

Ultrasensitive Nucleic Acid Assay Based on Cyclometalated Iridium(III) Complex with High Electrochemiluminescence Efficiency

Zhi-Hong Xu et al.

Summary: A sensitive electrochemiluminescence (ECL) biosensor based on a newly synthesized cyclometalated iridium(III) complex ((bt)(2)Irbza) was developed for miRNA detection, providing ultrahigh sensitivity with a detection limit of 82 aM. The ECL intensity of (bt)(2)Irbza was significantly enhanced by the oxidative-reductive behavior, showing 16.7 times relative efficiency compared to a commercial [Ru(bpy)(3)](2+) under the same conditions, thereby demonstrating promising potential for biosensing applications.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes

Shuai Liu et al.

Summary: The study introduces a rational design and combinatorial synthesis of zwitterionic phospholipidated polymers (ZPPs) for efficient mRNA delivery to spleen and lymph nodes, with potential for substantial immunotherapeutic applications.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Many Birds, One Stone: A Smart Nanodevice for Ratiometric Dual-Spectrum Assay of Intracellular MicroRNA and Multimodal Synergetic Cancer Therapy

Peng He et al.

Summary: The study presented an integrated smart nanodevice composed of Au@Cu2-xS@polydopamine nanoparticles and fuel DNA-conjugated tetrahedral DNA nanostructures for antitumor therapy and miRNA detection. Utilizing a SERS-FL dual-spectrum biosensor, the device achieved high detection sensitivity and low background signal for improved accuracy in diagnosing cancer cell miRNA.

ACS NANO (2021)

Article Multidisciplinary Sciences

Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading

Christopher A. Brosnan et al.

Summary: Researchers have generated a genome-wide map of active miRNAs in Caenorhabditis elegans, revealing cell-type-specific patterns of miRNAs loaded into Argonaute silencing complexes. This study demonstrates spatial and temporal dynamicism, flexibility of miRNA loading, and suggests miRNA regulatory mechanisms via AGO selectivity in different tissues and during ageing. Additionally, widespread changes in AGO-regulated gene expression were resolved by analyzing translatomes specifically in neurons, providing insights into AGO loading flexibility.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Multifunctional Clip Strand for the Regulation of DNA Strand Displacement and Construction of Complex DNA Nanodevices

Liquan Liu et al.

Summary: The development of the Clip tool expands the functionality of DNA strand displacement-based nanodevices, achieving multiple regulatory functions such as fine adjustment of reaction rates, allosteric strand displacement, selective activation, and reaction resetting. DNA walking machines constructed using this tool demonstrate controllable walking, concatenation, and programmable pathways, showcasing the versatility of the Clip-toehold-based DNA nanodevices.

ACS NANO (2021)

Article Chemistry, Analytical

Multifunctional Plasmonic Core-Satellites Nanoprobe for Cancer Diagnosis and Therapy Based on a Cascade Reaction Induced by MicroRNA

Duoduo Zhang et al.

Summary: The study constructed a multifunctional plasmonic core-satellites nanoprobe for clinical cancer diagnosis and therapy, which can be used for miRNA detection, targeting drug release, and therapy evaluation.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

Ultrasensitive and Simultaneous SERS Detection of Multiplex MicroRNA Using Fractal Gold Nanotags for Early Diagnosis and Prognosis of Hepatocellular Carcinoma

Jiamin Wu et al.

Summary: The magnetically assisted sandwich-type surface-enhanced Raman scattering (SERS) based biosensor achieved ultrasensitive and multiplex detection of three hepatocellular carcinoma-related miRNA biomarkers, showing promise in the diagnosis, prediction, monitoring, and staging of cancers.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Analytical

Near-Infrared Light-Initiated Photoelectrochemical Biosensor Based on Upconversion Nanorods for Immobilization-Free miRNA Detection with Double Signal Amplification

Mengjiao Hao et al.

Summary: A NIR-initiated PEC biosensor was developed for sensitive detection of AMI-related miRNA-133a in an immobilization-free format, showing high detection sensitivity and linear selectivity.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Spatially Selective Imaging of Mitochondrial MicroRNAs via Optically Programmable Strand Displacement Reactions

Jian Zhao et al.

Summary: This study presents a DNA nanoreporter technology for imaging of mitomiRs in living cells through near-infrared light-controlled DNA strand displacement reactions, allowing spatially-restricted imaging of cancer-related mitomiRs with improved detection accuracy. Furthermore, it demonstrates in vivo imaging of mitomiRs through spatiotemporally-controlled delivery and activation, illustrating a simple methodology for investigating physiological events associated with mitomiRs.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Genetically Encoded Sensor Enables Endogenous RNA Imaging with Conformation-Switching Induced Fluorogenic Proteins

Wen-Jing Zhou et al.

Summary: Genetically encoded molecular tools are crucial for live cell RNA imaging, and this study develops a new sensor system using conformation switching RNA induced fluorogenic proteins that enable multicolor imaging and signal amplification of endogenous RNAs. The sensor is designed with an RNA sensing module and a degron-fused fluorescent protein reporter for high-contrast imaging of RNA abundance and dynamics in live cells. Furthermore, the sensor system is extended to a multicolor palette and engineered into a signal amplifier, providing a valuable platform for RNA imaging in biomedical research and clinical theranostics.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Controlling the DNA Hybridization Chain Reaction

C. Adrian Figg et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Analytical

Cascade Transcription Amplification of RNA Aptamer for Ultrasensitive MicroRNA Detection

Mengxi Zhou et al.

ANALYTICAL CHEMISTRY (2019)

Article Chemistry, Analytical

Bidirectional Electrochemiluminescent Sensing: An Application in Detecting miRNA-141

Zhi-Hong Xu et al.

ANALYTICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor

Tianyu Xue et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Integrated extracellular microRNA profiling for ovarian cancer screening

Akira Yokoi et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Analytical

Simultaneous Surface-Enhanced Raman Spectroscopy Detection of Multiplexed MicroRNA Biomarkers

Wen Zhou et al.

ANALYTICAL CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Prevention of Self-Quenching in Fluorescent Silica Nanoparticles by Efficient Energy Transfer

Damiano Genovese et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Multidisciplinary Sciences

MicroRNA-34a regulates cardiac ageing and function

Reinier A. Boon et al.

NATURE (2013)

Review Multidisciplinary Sciences

The microcosmos of cancer

Amaia Lujambio et al.

NATURE (2012)

Article Chemistry, Multidisciplinary

Two-Temperature Hybridization for Microarray Detection of Label-Free MicroRNAs with Attomole Detection and Superior Specificity

Jeong Min Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)