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Letter Critical Care Medicine

Circulating Biomarkers in Young Individuals with Low Peak FEV1

Nuria Olvera et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

Article Critical Care Medicine

Plasticity of Individual Lung Function States from Childhood to Adulthood

Gang Wang et al.

Summary: Recent evidence emphasizes the significance of optimal lung development during childhood for lifelong health. This study explored the plasticity of individual lung function states during childhood and found that catch-up and growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction in adulthood.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

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Editorial Material Critical Care Medicine

Evolution of Lung Function within Individuals: Clinical Insights and Data-driven Methods

Adnan Custovic et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

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Article Respiratory System

Increased cytotoxic T-cells in the airways of adults with former bronchopulmonary dysplasia

Petra Um-Bergstrom et al.

Summary: Young adults with former BPD have a T-cell subset pattern in the airways resembling features of COPD. Our findings suggest that CD3+CD8+ T-cells are involved in mechanisms behind chronic airway obstruction in these patients.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Critical Care Medicine

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan

Alva Agusti et al.

Summary: Recent research findings challenge the traditional view of chronic obstructive pulmonary disease (COPD) as solely caused by smoking in genetically susceptible individuals. Instead, COPD is now understood as the potential end result of gene-environment interactions accumulated over an individual's lifetime. Future research should aim to understand the dynamic interactions between genes and the environment by integrating information from basic and clinical omics with exposures over time. Additionally, COPD should be viewed as a clinical syndrome rather than a single disease.

LANCET RESPIRATORY MEDICINE (2022)

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Editorial Material Critical Care Medicine

Definition and Nomenclature of Chronic Obstructive Pulmonary Disease Time for Its Revision

Bartolome Celli et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Respiratory System

Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

Gang Wang et al.

Summary: This study investigated the prevalences of obstructive and restrictive spirometric phenotypes and their associations with respiratory risk factors in different age groups in European cohorts. Results suggest that early-life risk factors may be related to different spirometric phenotypes across ages.

ERJ OPEN RESEARCH (2021)

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Article Respiratory System

Paediatric reproducibility limits for the forced expiratory volume in 1 s

Sanja Stanojevic et al.

THORAX (2020)

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Article Respiratory System

Standardisation of spirometry

MR Miller et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

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