Journal
ADVANCED MATERIALS
Volume 28, Issue 4, Pages 694-700Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503740
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Funding
- National Natural Science Foundation of China [31370923, 21201150, 21571155, 91127003]
- National Science and Technology Major Project [2012ZX10001-009]
- Fundamental Research Funds for the Central Universities of China from Zhejiang University
- Municipal Healthcare Joint-Innovation Major Project of Guangzhou, China [201508020256]
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Dual-functional biomineral-vaccine core-shell nanohybrids are obtained using recombinant adenovirus serotype 5 (rAd5) as templates, which efficiently masks the neutralizing epitope of vaccines and preserve their original immunogenicity. The versatile vaccine hybrid can evade the preexisting anti-Ad5 immunity, leading to boosted multifunctional antigen-specific cytokine-secreting T cell responses and presenting promising applications of vaccine-material hybrid for the rational design of vaccines.
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