Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 292, Issue -, Pages 52-57Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2016.01.013
Keywords
Multiple sclerosis; SF; Biomarker; YKL-40; GFAp; sCD14; MRI
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Funding
- Research Council Sweden
- Torsten Soderberg Foundation at the Royal Swedish Academy of Sciences
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YKL-40 (CHI3L1) is a glycoprotein predominantly produced by reactive astrocytes in chronic active MS lesions, which are common in secondary progressive MS. In this study, YKL-40 was investigated in different stages of MS and in relation to MRI findings. YKL-40 levels in CSF samples from two independent patient cohorts of MS patients were determined with ELISA. CSFYKL-40 was increased in patients with active relapsing-remitting MS and correlated with the number of gadolinium enhancing lesions. Patients with secondary progressive MS had similar high levels of YKL-40, whereas not active relapsing-remitting MS patients had YKL-40 levels comparable to healthy controls. (C) 2016 Elsevier B.V. All rights reserved.
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