Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 291, Issue -, Pages 18-27Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2015.12.004
Keywords
Microglia; Neonatal hypoxia-ischemia; Neuroinflammation; Cerebral atrophy
Categories
Funding
- NIH [P30 HD03352]
- NIH/NINDS [1K08NS078113]
- [KL2 TR000428]
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We previously found increased microglial proliferation and pro-inflammatory cytokine release in infant mice compared to juvenile mice after hypoxia-ischemia (HI). The aim of the current study was to assess for differences in the effect of microglial suppression on HI-induced brain injury in infant and juvenile mice. HI was induced in neonatal (P9) and juvenile (P30) mice and minocycline or vehicle was administered at 2 h and 24 h post-HI. P9 minocycline-treated mice demonstrated early but transient improvements in neurologic injury, while P30 minocycline-treated mice demonstrated sustained improvements in cerebral atrophy and Morris Water Maze performance at 60 days post-HI. (C) 2015 Elsevier B.V. All rights reserved.
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