Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 292, Issue -, Pages 116-125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2016.01.022
Keywords
Neuro-HIV; HIV-1 transgenic rat; Viral proteins; Neuropathology; Astrocytic loss; Neurotoxicity
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Funding
- Center for Infectious Disease Imaging (CIDI), National Institutes of Health
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The transgenic HIV-1 rat (Tg) is a commonly used neuroHlV model with documented neurologic/behavioral deficits. Using immunofluorescent staining of the Tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. We saw mild microglial activation in young Tg brains, but this decreased with age. There were no differences in neurogenesis potential suggesting a neurodegenerative rather than a neurodevelopmental process. Gp120 CSF levels exceeded serum gp120 levels in some animals, suggesting local viral protein production in the brain. Further probing of the pathophysiology underlying astrocytic injury in this model is warranted. Published by Elsevier B.V.
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