Current advancements related to phytobioactive compounds based liposomal delivery for neurodegenerative diseases

Neurodegenerative diseases are the most widely affected disease condition in an aging population. The treatment available reduces the elevated manifestations but is ineffective due to the drug's poor bioavailability, plasma stability, and permeability across the blood-brain barrier (BBB). Until now, no therapeutic compound has been able to stop the progression of neurodegenerative disease. Even the available therapeutic moiety manages it with possible adverse effects up to the later stage. Hence, phytobioactive compounds of plant origin offer effective treatment strategies against neurodegenerative diseases. The only difficulty of these phytobioactive compounds is permeability across the BBB. Engineered nanocarriers such as liposomes provide high lipid permeability across BBB. Liposomes have unique physicochemical properties that are widely investigated for their application in diagnosing and treating neurodegenerative diseases. The surface modification on liposomes by peptides, anti-bodies, and RNA aptamers offers receptor targeting. These brain-targeted approaches by liposomes improve the efficacy of phytoconstituents. Additional surface modification methods are utilized on liposomes, which in-creases the brain-targeted delivery of phytobioactive compounds. The marketing strategy of the liposomal de-livery system is in its peak mode, where it has the potential to modify the existing therapy. This review will summarize the brain target liposomal delivery of phytobioactive compounds as a novel disease-modifying agent for treating neurodegenerative diseases.

Automated summary

Neurodegenerative diseases are common in aging populations, and current treatments have limited effectiveness due to poor drug bioavailability and permeability across the blood-brain barrier. Phytochemical compounds of plant origin offer potential treatments, but their delivery to the brain is challenging. Liposomes, engineered nanocarriers with high BBB permeability, show promise for diagnosing and treating neurodegenerative diseases. Surface modifications on liposomes improve receptor targeting and the delivery of phytoconstituents to the brain. This review highlights the potential of liposomal delivery for treating neurodegenerative diseases.